Rapid evolution and molecular convergence in cryptorchidism-related genes associated with inherently undescended testes in mammals

Table 2 Positively selected genes and sites in ascrotal IDT and UDT mammals detected by branch-site model

Gene	2∆ (lnL)	p value (< 0.05)	Adjusted p value (< 0.05)	ω value	Positively selected sites† (PP > 0.8)
FLNA	90.45473	< 0.0001	< 0.0001	19.77482	6 (0.902) 432 (0.859) 1115 (0.818) 1764 (0.876) 2058 (0.999) 2399 (0.912)
DOCK1	66.31111	< 0.0001	< 0.0001	3.01947	120 (0.948) 781 (0.899) 1817 (0.927)
CSMD3	45.53421	< 0.0001	< 0.0001	22.94946	391 (0.961) 2238 (0.874) 2314 (0.813) 3022 (0.934) 3105 (0.927) 3341 (0.853) 3416 (0.828) 3565 (0.990)
MCMBP	23.477574	< 0.0001	< 0.0001	29.13722	190 (0.871) 249 (0.856) 273 (0.986) 401 (0.867)
FANCE	21.201804	< 0.0001	< 0.0001	4.29612	59 (0.818) 150 (0.994) 192 (0.998) 265 (0.863) 427 (0.896)
FBXL18	21.03184	< 0.0001	< 0.0001	33.89202	19 (0.980) 160 (0.813)
ARMC4	18.634242	< 0.0001	0.0007	4.42802	194 (0.917) 386 (0.931) 667 (0.877) 978 (0.950)
DEPTOR	18.15214	< 0.0001	0.0009	4.59605	184 (0.908)
ACTA1	17.687794	< 0.0001	0.0010	3.40263	93 (0.818) 302 (0.962)
JAG1	15.491652	< 0.0001	0.0028	4.20226	1006 (0.853) 1136 (0.926)
AIMP2	15.104846	0.0001	0.0032	22.04281
RAF1	13.280048	0.0003	0.0077	5.13164
CCDC73	11.117498	0.0009	0.0229	3.61345	418 (0.946) 440 (0.901) 826 (0.998) 1027 (0.966)

^†PPs of Bayes Empirical Bayes (BEB) analysis with P > 0.8 were regarded as amino acid candidates for selection

ISSN: 2730-7182