Fig. 4

Evolutionary tree of the combined D1- and D2-domains for different Cdc48 family members. The tree was calculated using an alignment of concatenated D1- and D2-domains of 48 eukaryotic species comprising 270 sequences. The tree shows a distinct separation of the individual Cdc48 family members (highlighted in different colors as in Fig. 2). Statistical support values are annotated at selected inner edges. Note that the most divergent member, Yta7, was omitted