Table 1 Distribution of SNPs according to the Clusters of Orthologous Groups (COG) classification. The binomial test was calculated using Excel as follows: BINOMIAL DIST (Number of SNPs, Total number of SNPs, Gene length/Total gene length, 1)

Secondary metabolites biosynthesis, transport and catabolism

Q

169

111

280

85

186303

0.016339104

Energy production and conversion

C

128

77

205

104

141315

0.00956263

Lipid transport and metabolism

I

110

75

185

86

108423

0.551376551

Amino acid transport and metabolism

E

112

58

170

85

111717

0.075317667

Transcription

K

100

54

154

68

60555

0.999999395

Signal transduction mechanisms

T

102

41

143

43

55596

0.99999919

Inorganic ion transport and metabolism

P

92

40

132

70

100593

0.000946095

Replication, recombination and repair

L

80

46

126

51

75246

0.463792377

Coenzyme transport and metabolism

H

83

42

125

60

63582

0.955338675

Carbohydrate transport and metabolism

G

83

33

116

57

82752

0.017486939

Cell wall/membrane/envelope biogenesis

M

70

39

109

57

70737

0.164200506

Post-translational modification, protein turnover, and chaperones

O

41

31

72

42

54294

0.016391663

Cell cycle control, cell division, chromosome partitioning

D

34

18

52

22

38130

0.059214452

Nucleotide transport and metabolism

F

28

22

50

33

36285

0.073929704

Defense mechanisms

V

29

14

43

26

34749

0.017540819

Intracellular trafficking, secretion, and vesicular transport

U

6

6

12

7

8544

0.310996283

Cell motility

N

1

0

1

0

0

1

Not in COGs

R

441

228

669

386

325323

0.999999959

General function prediction only

R

250

136

386

189

238986

0.156980544

Function unknown

S

116

69

185

106

101895

0.838428538