Fig. 4From: Evolution of substrate recognition sites (SRSs) in cytochromes P450 from Apiaceae exemplified by the CYP71AJ subfamilyPotential active site configurations for five CYP71AJ groups. The homology models were constructed in CPHmodels-3.2 and VOIDOO was used for cavity calculations. SRS1: blue; SRS2 + 3: green; SRS4: yellow; SRS5: orange; SRS6: red; and heme-group: grey. The three-amino-acid motives in SRS1 that are likely important for substrate acceptance are indicated with dashed ovals. Residue differences between groups II-5 and II-6 are marked with black. Other residue likely to be important for the active sites are discussed in the text. a) CYP71AJ3, b) CYP71AJ4, c) CYP71AJ6 and CYP71AJ12, d) CYP71AJ32Back to article page