From: The role of positive selection in determining the molecular cause of species differences in disease
Cluster number | Genes in cluster | pvalue for cluster size given previous clusters | pvalue for cluster given number of interactions per gene ** |
---|---|---|---|
Chimpanzee | Â | Â | Â |
1 | PCSK5, BMP4, PHOX2A | 0.981 | 0.0013 |
2 | LHB, OTX1, JUB | 0.391 | 0.0001 |
3 | XPC, RAD23A | 0.519 | 0.0035 |
4 | NUCB1, PTGS1 | 0.346 | 0.0046 |
5 | ITGB6, ALOX12 | 0.227 | 0.0030 |
6 | MYO18A, TRADD | 0.131 | 0.0028 |
7 | GSTP1, MAP2K4 | 0.075 | 0.0442 |
8 | PEX12, PEX19 | 0.036* | 0.0003 |
9 | NRP1, MSI1 | 0.019* | 0.0008 |
Dog | Â | Â | Â |
1 | CFP, TAL1, SERPINB1, MMP12, PRF1, BCL2, HRG, ITGA5, COMP | 0.385 | < 0.0001 |
2 | CD79A, HCLS1, LCP2 | 0.209 | 0.0012 |
3 | SNTA1, DAG1, MUSK | 0.036* | 0.0002 |
4 | LRP5, SLC2A2 | 0.171 | 0.0026 |
5 | ALB, MCAM | 0.082 | 0.0123 |
Hominid | Â | Â | Â |
1 | CCL19, CD86, MADCAM1 | 0.335 | 0.0015 |
2 | MRC2, COL4A4 | 0.186 | 0.0028 |
3 | DRD2, TH | 0.045* | 0.0488 |
4 | ITGAV, AZGP1 | 0.008* | 0.0080 |
Mouse | Â | Â | Â |
1 | HLA-DRB1, HLA-DQA2 | 0.755 | 0.0123 |
2 | C1R, C1QA | 0.288 | 0.0030 |
Murid | Â | Â | Â |
1 | TLR5, CD86, PTGIR | 0.678 | 0.0001 |
2 | SCNN1G, SPTA1, HECW1 | 0.432 | 0.0021 |
3 | CNR1, RAPGEF1 | 0.190 | 0.0110 |
4 | F5, GP1BA | 0.064 | 0.0032 |
Rat | Â | Â | Â |
1 | CDKN2D, TRIM21, CDKN1B, CAST, ICAM1, CFD, ITGB2, C3 | 0.360 | < 0.0001 |
2 | KCNA4, ACTN2, PIK3R5 | 0.526 | 0.0016 |
3 | PIM1, RP9 | 0.280 | 0.0063 |
4 | ASPH, HDAC4 | 0.118 | 0.0053 |