Table 1 Gene and transcript annotation of protein-coding genes located on human chromosome Xq22.1-q22.2. Human WEX1 has arisen from duplication of WEX2, and human BEX5 is absent from the mouse genome. ^a Levels of transcript expression in the brain are based on Microarray gene hybridization results [57]. Accession codes and expression tags are shown in parentheses. A gene expression in the brain is absent (-), present (+), or high relative to other tissues (++). Abbreviations: GLA, Galactosidase, alpha; HNRPH2, Heterogeneous nuclear ribonucleoprotein H2; GASP, G protein-coupled receptor-associated sorting; NXF, Nuclear RNA export factor; PRAMEL3, Preferentially expressed in melanoma like 3; WEX, WWbp5-like gene family; BEX, B rain-e xpressed X-linked; TCP11B, T-complex 11 B; TMSNB, Thymosin, beta, identified in neuroblastoma; RAB40A, Ras oncogene family member; MSP, Microsomal signal peptidase 23 kDa subunit (SPase 22 kDa subunit); KIRL2, Killer immunoglobulin-like receptor-like 2; KIR3DL1, Killer immunoglobulin-like receptor 3DL1; MORF4L2, Mortality factor 4 like 2;

NM_000169

NP_000160

GLA

99424654

99434808

+ (GLA/214430_at)

NM_019597

NP_062543

HNRPH2

99435140

99440975

+ (HNRPH2)

NM_152583 (BC036206)

NP_689796

Q8K2R3

GASP4

99512319

99560303

+ (gnf1h06491_at)

NM_016608

NP_057692

Alex1/Q9P291

GASP7

99577371

99581530

+ (ARMCX1)

GASP10ψ

99624346

99624903

N/A

NM_019007

NP_061880

Q9NWJ3

GASP10

99641972

99644848

+ (FLJ20811)

NM_016607

NP_057691

Alex3, Q9UH62

GASP6

99649976

99654688

+ (ARMCX3)

NM_177949

NP_808818

Alex2, O60267

GASP9

99682129

99686692

+ (ARMCX2)

NM_032946

NP_116564

NXF5

99858942

99884406

N/A

AK094141

XP_040486

KIAA1789

99910469

99958857

N/A

NM_080390 (AL540086)

NP_525129

my048

WEX1

100152572

100154538

++ (AF063606)

BC071675

N/A

WEX2

100167309

100169228

N/A

BC042818

N/A

BEX5

100180542

100182792

N/A

NM_017809 (BX647232)

NP060279

NXF2

100242137

100353489

+ (NXF2/220257_x_at)

NM_017809 (BX647232)

NP060279

NXF2

100387175

100498589

+ (NXF2/220257_x_at)

NM_021992

NP_068832

TMSNB

100540461

100543504

++ Fetal brain (205347_s_at)

NM_207512

NP_997395

NXF4

100576750

100598478

N/A

NM_022838

NP_073749

Q9H969

GASP5

100626014

100630940

+ (FLJ12969/219335_at)

NM_014710

NP_055525

Q43168

GASP1

100678299

100685235

++ (GASP/204793_at)

NM_138437 (AK123832)

NP_612446

Q96D09

GASP2

100739148

100744517

N/A

NM_030639

NP_085142

Q9BE11

GASP3

100747511

100779225

+ (KIAA1701/213709_at)

Rab40A-like

100964038

100965103

++ (108_g_at)

NM_018476 (BX098763)

NP_060946

BEX1, HBEX2

BEX2

101089445

101090956

++ (BEX1/218332_at)

NM_022052

NP_071335

NXF3

101102606

101119879

- (NXF3/220110_s_at)

AK000959

N/A

Bex4

BEX4

101241922

101243977

++ (BEXL1/ 215440_s_at, 40916_at**)

NM_153333 (AL709034)

NP_699164

Wex3

WEX3

101279783

101281945

N/A

AL550633

N/A

Wex4

WEX4

101300507

101303513

++ (gnf1h07374_s_at, gnf1h07373_at)

NM_032621 (AL520932)

NP_116010

Bex2, mouseBex1

BEX1

101336132

101337663

N/A

NM_152278 (H09952)

NP_689491

Wex5

WEX5

101357022

101359108

++ (gnf1h06733_at)

NM_016303 (BF028506)

NP_057387

Wex6

WEX6

101383280

101385238

+ (WBP5 / 217975_at)

NM_206915

NP_996798

Ngfrap1

BEX3

101403125

101404856

++ (NGFRAP1/217963_s_at)

NM_080879

NP_543155

RAB40A

101526538

101546274

N/A (RAB40A, 217589_at, 33477_at)

NM_024863 (AK024827)

NP_079139

Wex7

WEX7

101603016

101614300

++ (FLJ21174)

NM_032926

NP_116315

Wex8

WEX8

101634691

101636711

++ (MGC15737)

NM_004780

NP_004771

TCEAL1

WEX9

101655759

101657725

++ (TCEAL1)

NM_012286

NP_036418

MORF4L2

101702290

101713453

+ MORF4L2