From: Multiple genetic switches spontaneously modulating bacterial mutability
Gene | Location | DNA repeatsa | Allele | Substituted basesb | Protein | Description |
---|---|---|---|---|---|---|
mutL | 201-218 | GCTGGCGCTGGCGCTGGCc | mutL Locked-1 | GCT TGCCCTGGCGCTGGCc | LALALA | lies in a region that forms a lid over the ATP-binding pocket of MutL protein |
 |  |  | mutL L1-UL | GCT GGCGCTGGCGCTGGCc |  |  |
 | 190-195 | AAAAAA | mutL Locked-2 | AA GAAA | KK | lies in a relatively disordered structure of ATP-binding pocket of MutL protein |
 | 491-496 | gAAAAAA | mutL Locked-3 | gA GAAGA | EK | lies in α helic E of MutL protein |
 | 735-743 | CACCACCACg | mutL Locked-4 | CAC GACTACg | TTT | lies in a relatively disordered structure of MutL C-terminal demonization domain |
 | 82-90 | AAAGAGCTG | mutL Locked-C | AAAGAGCTT | KEL | lies in the α helic A of MutL protein |
6bpΔmutL | 201-212 | GCTGGCGCTGGc | 6bpΔmutLLocked | GCT TGCGCTGGCc | LALA | lies in a region that forms a lid over the ATP-binding pocket of MutL protein |
mutS | 1189-1195 | AAAAAAA | mutS Locked | AA GAAAA | KK | lies in the C-terminal end of helic α16, which forms the core domain of the MutS protein |