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Fig. 10 | BMC Evolutionary Biology

Fig. 10

From: Phylotranscriptomics suggests the jawed vertebrate ancestor could generate diverse helper and regulatory T cell subsets

Fig. 10

A full set of T helper and T regulatory cell associated genes existed in the jawed vertebrate ancestor. The figure and gene selection are based on Fig. 5 from Venkatesh et al. [5], but here refer to the ancestral jawed vertebrate gene set rather than that of cartilaginous fishes. Boxed lineages were predicted to have emerged in the ancestor of jawed vertebrates by Venkatesh et al. [5] (black boxed lineages), by this study (red boxed lineages), or by this study and Dijkstra [18] (blue boxed lineages). All genes listed, except for IL-9 and IL-2Rα, have now been identified in cartilaginous fishes

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