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Fig. 1 | BMC Evolutionary Biology

Fig. 1

From: Phylotranscriptomics suggests the jawed vertebrate ancestor could generate diverse helper and regulatory T cell subsets

Fig. 1

Summary of the presence/absence of major mammalian CD4+ T-cell lineages and associated genes in the jawed vertebrate ancestor. The figure and gene selection are based on Fig. 5 from Venkatesh et al. [5]. Boxed lineages were predicted to have emerged in the ancestor of jawed vertebrates by Venkatesh et al. [5] (black boxed lineages), or by Dijkstra [18] (blue boxed lineages). Crossed out genes are those thought to be absent from cartilaginous fishes and the vertebrate ancestor, while blue encircled genes are those that Dijkstra later predicted to in fact be present [18]. Dotted box/circle edges indicate uncertainty of gene or lineage presence(e.g. for IL-2R, FOXP3 [18])

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