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Fig. 7 | BMC Evolutionary Biology

Fig. 7

From: Cysteine boosters the evolutionary adaptation to CoCl2 mimicked hypoxia conditions, favouring carboplatin resistance in ovarian cancer

Fig. 7

ES2 cells present metabolic diversity in adverse environments. ROS histogram for a. ES2-N cells, b. ES2-H cells, c. OVCAR3-N cells, d. OVCAR3-H cells in a free drug environment for 48 h of experimental conditions, and ROS histogram for e. ES2-N cells, f. ES2-H cells, g. OVCAR3-N cells and h. OVCAR3-H in the presence of carboplatin. NN – cells selected under normoxia and cultured under normoxia (grey line); NNC – cells selected under normoxia and cultured under normoxia supplemented with cysteine (blue line); NH – cells selected under normoxia and cultured under hypoxia mimicked with CoCl2 (red line); NHC – cells selected under normoxia and cultured under hypoxia mimicked with CoCl2 supplemented with cysteine (green line); HN – cells selected under hypoxia mimicked with CoCl2 and cultured under normoxia (grey line); HNC – cells selected under hypoxia mimicked with CoCl2 and cultured under normoxia supplemented with cysteine (blue line); HH – cells selected under hypoxia mimicked with CoCl2 and cultured under hypoxia (red line); HHC – cells selected under hypoxia and cultured under hypoxia mimicked with CoCl2 supplemented with cysteine (green line)

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