Fig. 2

Secondary structure analysis of lincRNAs. a Distribution of Z-scores with folding strength (FS). Both are highly correlated (rho=0.46, p-value 2.2e16) which indicates that strongly folded sequences also tend to be more stable than their shuffled controls. b Distribution of Z-scores obtained from MFE of lincRNAs compared to shuffled sequences. A negative correlation (rho=-0.22, p-value 2.2e16) indicates than thermodynamically stable sequences (i.e longer because MFE scales with length) have higher Z-scores although several short sequences outliers with very strong Z-scores are present. c Comparison of Z-scores for FS obtained between lincRNAs and 10000 CDS from the seven species. CDS shows significantly bigger FS than lincRNAs. d Comparison of Z-scores for MFE calculations obtained between lincRNAs and 1O000 CDS from the seven species. Z-scores are significantly higher for lincRNAs