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Fig. 7 | BMC Evolutionary Biology

Fig. 7

From: Reconstruction of the evolution of microbial defense systems

Fig. 7

Examples of defense gene gain. The trees for the ATGC genomes, reconstructed from concatenated alignments of nucleotide sequences of common orthologs [29] are shown in the left part of each panel. Defense system loci are schematically depicted in the right part of each panel. Homologous genes are highlighted in matching colors. Genes that are rare or unique in these regions are shown as blank shapes. Genes are labeled by the gene names or by NCBI CDD profile names. Gained genes are shown by red outline. Conserved flanking genes are shown by blue outline. a Acquisition of RM-related genes in Corynebacterium diphtheriae BH8. b Recombination in situ in the CRISPR-cas locus of Clostridium botulinum strains. The cas genes and CRISPR-Cas system subtypes are labeled according to the current CRISPR-Cas system classification and nomenclature [34]. The cas6 gene not affected by recombination are is highlighted by yellow outline. The phylogenetic tree for the cas6 nucleotide sequences is schematically shown opposite the genome tree. c Acquisition of Abi genes in the Propionibacterium acnes strains SK137 and HL096PA1

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