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Table 4 Annotation of the ±10 genomic neighborhood of trpE from B. subtilis

From: Assessing in silico the recruitment and functional spectrum of bacterial enzymes from secondary metabolism

BGC0000309; SM* bsu:BSU31990 Isochorismate synthase DhbC (EC 5.4.4.2) ↔ PM bsu:BSU22680 trpE; E-value 3.0E-20

E_PM

K_SM

KEGG Annotation

Pathways in ±10/±2 Nh

  

bsu:BSU22590 ypiA; TPR repeat-containing protein YpiA

16/5 bsu01110 Biosynthesis of secondary metabolites

13/5 bsu01130 Biosynthesis of antibiotics

12/5 bsu00400 Phenylalanine, tyrosine and tryptophan biosynthesis

12/5 bsu01230 Biosynthesis of amino acids

2/0 bsu00401 Novobiocin biosynthesis

2/0 bsu00260 Glycine, serine and threonine metabolism

2/0 bsu00900 Terpenoid backbone biosynthesis

1/0 bsu02020 Two-component system

1/0 bsu00790 Folate biosynthesis

1/0 bsu02030 Bacterial chemotaxis

1/0 bsu00240 Pyrimidine metabolism

1/0 bsu00230 Purine metabolism

1/0 bsu00340 Histidine metabolism

1/0 bsu00360 Phenylalanine metabolism

1/0 bsu00130 Ubiquinone and other terpenoid-quinone biosynthesis

1/0 bsu00350 Tyrosine metabolism

P

S

bsu:BSU22600 aroE; 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19)

P

S

bsu:BSU22610 tyrA; prephenate dehydrogenase (EC 1.3.1.12)

P

S

bsu:BSU22620 hisC; histidinol-phosphate aminotransferase (EC 2.6.1.9)

P

S

bsu:BSU22630 trpA; tryptophan synthase alpha chain (EC 4.2.1.20)

P

S

bsu:BSU22640 trpB; tryptophan synthase beta chain (EC 4.2.1.20)

P

S

bsu:BSU22650 trpF; N-(5'-phosphoribosyl)anthranilate isomerase (EC 5.3.1.24)

P

S

bsu:BSU22660 trpC; indole-3-glycerol phosphate synthase (EC 4.1.1.48)

P

S

bsu:BSU22670 trpD; anthranilate phosphoribosyltransferase (EC 2.4.2.18)

P

S

bsu:BSU22680 trpE; anthranilate synthase component 1 (EC 4.1.3.27)

P

S

bsu:BSU22690 aroH; chorismate mutase AroH (EC 5.4.99.5)

P

S

bsu:BSU22700 aroB; 3-dehydroquinate synthase (EC 4.2.3.4)

P

S

bsu:BSU22710 aroF; chorismate synthase (EC 4.2.3.5)

P

 

bsu:BSU22720 cheR; chemotaxis protein methyltransferase (EC 2.1.1.80)

P

S

bsu:BSU22730 ndk; nucleoside diphosphate kinase (EC 2.7.4.6)

P

S

bsu:BSU22740 hepT; heptaprenyl diphosphate synthase component 2 (EC 2.5.1.30)

 

S

bsu:BSU22750 ubiE; demethylmenaquinone methyltransferase (EC 2.1.1.-)

P

S

bsu:BSU22760 hepS; heptaprenyl diphosphate synthase component 1 (EC 2.5.1.30)

  

bsu:BSU22770 mtrB; transcription attenuation protein MtrB

P

 

bsu:BSU22780 folE; GTP cyclohydrolase 1 (EC 3.5.4.16)

  

bsu:BSU22590 ypiA; TPR repeat-containing protein YpiA

  1. The first line gives the name of the MIBiG cluster containing the considered SM* enzyme, the annotation of the SM* and the related putative PM enzyme from the same genome, and the BLAST E-value resulting from the comparison of the corresponding two protein sequences
  2. The following lines characterize the ±10 genomic neighbourhood of the putative PM enzyme. A “P” in column “E_PM” indicates that this enzyme function, i. e. EC number, occurs in enzymes PM* and an “S” in column “K_SM” indicates that KEGG assigned this enzyme function to the pathway “Biosynthesis of secondary metabolites”. The column named “KEGG Annotation” lists KEGG-ID, function and EC number of the gene products. The column named Pathways in ±10/±2 Nh” lists the number of genes from the corresponding two neighborhoods of the putative PM enzyme that belong to the listed KEGG pathways. For this table, the gene annotations taken from the respective html-page were shortened for the sake of brevity
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BMC Ecology and Evolution

ISSN: 2730-7182

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