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Table 1 Individual HEV GI protein viral homologues

From: Ancient recombination events and the origins of hepatitis E virus

Protein aClosest Hepeviridae homologue E-value Percent identity 1st-ranked Non-HEV viral homologue Family/Genus E- value Percent identity 2nd-ranked Non-HEV viral homologue Family/Genus E- value Percent identity
Polyprotein (ORF1) (NP056779) Orthohepevirus C 0 57 % bHelicoverpa armigera stunt virus (HASV) Alphatetraviridae Omegatetravirus 1.74 × 10-262.03 × 10-7 26 % 29 % bDendrolimus punctatus tetravirus Alphatetraviridae/Omegatetravirus 1.28 × 10-21 7.42 × 10-8 7.42 × 10-8 25 % 25 % 20 %
Capsid (ORF2) (NP056788) Orthohepevirus C 0 57 % Porcine astrovirus Astroviridae/Astrovirus 2.02 × 10-12 21 % Chicken astrovirus Astroviridae/Astrovirus 2.74 × 10-12 26 %
Phosphoprotein (ORF3) (NP056787) None found - - None found - - - None found - - -
Methyltransferase (NP056780) Orthohepevirus C 5.47 × 10-65 59 % HASV Alphatetraviridae Omegatetravirus 5.88 × 10-7 33 % Frangipani mosaic virus Virgaviridae/ Tobamovirus 6.50 × 10-6 30 %
Y domain (NP056781) Orthohepevirus C 1.0 × 10-96 65 % Hop latent virus Betaflexiviridae Carlavirus 2.0 × 10-18 12 % Blueberry scorch virus Betaflexiviridae Carlavirus 6.0 × 10-18 12 %
PCP (Protease) (NP056782) Orthohepevirus C 1.0 × 10-10 37 % None found - - - None found - - -
PPR (NP056783) None found - - None found - - - None found - - -
Macro domain (X) (NP056784) Orthohepevirus C 1.73 × 10-45 56 % Aura virus Togaviridae/ Alphavirus 4.61 × 10-8 36 % Whataroa virus Togaviridae/Alphavirus 5.95 × 10-8 36 %
Helicase (NP056785) Orthohepevirus C 7.00 × 10-87 62 % Turnip vein clearing virus Virgaviridae/ Tobamovirus 6.04 × 10-13 31 % Maracuja mosaic virus Virgaviridae/ Tobamovirus 1.07 × 10-12 30 %
RdRp (NP056786) Orthohepevirus C 3.64 × 10-177 59 % Tick-borne tetravirus-like virus Unclassified virus 7.82 × 10-20 33 % Chara australis virus Unclassified virus 2.98 × 10-11 34 %
  1. a Closest Hepeviridae homologue, excluding HEV taxonomic id (GenBank taxid #12161) sequences
  2. bHASV has two distinct homologous fragments; Dendrolimus punctatus tetravirus has three distinct homologous fragments to HEV GI polyprotein