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Fig. 3 | BMC Evolutionary Biology

Fig. 3

From: Ancient recombination events and the origins of hepatitis E virus

Fig. 3

HEV GI ORF1 viral homologues. Selected Hepeviridae ORF1 protein sequences, and non-Hepeviridae protein sequences, were aligned to the translated prototype HEV GI ORF1 using Blastp. Homologues are organized into color-coded viral families. The organization of the individual proteins encoded by the HEV ORF1 is illustrated at the top. MT = Methyltransferase; Y = Y-domain; Pro = Papain-like cysteine protease; Z = Z region, PPR = Polyproline region; X = “X” or macro domain; Hel = Helicase; RdRp = RNA-dependent RNA polymerase. Green shading indicates 100 % similarity, light green when 80-99 %, yellow when 60-79 % and grey when <60 % similarity. Similarity is scored by all pairs of sites in any given column having a score according to the Blosum62 matrix, which exceeds a predetermined threshold value of ≥ 1. Positive scores occur between amino acids of similar physicochemical properties

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