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Table 1 D. discoideum gene products with similarity to the HAP1_N domain region of Drosophila Milton and human TRAK1 proteins

From: Huntingtin-associated protein 1: Eutherian adaptation from a TRAK-like protein, conserved gene promoter elements, and localization in the human intestine

 

Gene symbol (Gene name description)

Gene product

Description

E value

(<0.1)

Common Hits

fimC

(FIMbrin)

Fimbrin-3

Actin binding protein with 4 calponin homology domains

TRAK1: 2×10−6

Milton: 2×10−4

mhcA

(Myosin Heavy Chain A)

Myosin II heavy chain

Myosin II heavy chain, component of the actin-based molecular motor (conventional myosin); has actin-activated ATPase activity;

TRAK1:7×10−3

Milton: 3×10−4

DDB_G0290503

DDB0346607

Hypothetical protein predicted to be involved in meiosis and the synaptonemal complex

TRAK1: 5×10−5

Milton: 0.011

fimD

(FIMbrin)

Fimbrin-4

Actin binding protein with 4 calponin homology domains

TRAK1: 0.001

Milton: 0.079

kif4

(KInesin Family member 4)

Kinesin family member 4

Member of the CENP-E subfamily, predicted to play a role in mitosis

TRAK1: 0.01

Milton: 0.055

DDB_G0289761

DDB0348198

Not yet annotated

TRAK1: 0.051

Milton: 0.013

Additional TRAK1 hits

myoJ

(MYOsin)

myosin-5b

Conditional processive motor protein that can move over long distances along F-actin without disassociating

0.001

smc1

(Structural Maintenance of Chromosome)

structural maintenance of chromosome protein

Functions in chromosome dynamics

0.021

zipA

(ZIPper)

zipper-like domain-containing protein

-

0.022

kif9

(KInesin Family member 9)

Kinesin family member 9

Plays a role in connecting the centrosome with the nucleus

0.067

kif1

(KInesin Family member 1)

Kinesin-3

Kinesin family member 1; ortholog of C. elegans Unc104 and mammalian KIF1A, involved in intracellular transport

0.09

DDB_G0287325

AP2 complex protein Eps15

Similar to mammalian EPS15, a clathrin adaptor that binds to the AP2 alpha subunit in mammalian cells

0.033

DDB_G0288073

Nucleoprotein TPR

-

0.016

DDB_G0271334

C2 calcium/lipid-binding (CaLB) region and dilute domain-containing protein

Contains a dilute domain, found at the carboxyl terminus of non-muscle myosin V

0.061

Additional Milton hits

rad50

(Similar to RADiation sensitive mutant)

DNA recombination/repair protein

Similar to S. cerevisiae RAD50, involved in processing double-strand DNA breaks with Mre11.

0.001

sun1

(Sad1p and UNC-84)

SUN domain-containing protein 1

Localizes to the inner and outer nuclear membrane, mediates the attachment between centrosome and nucleus, associates the centromere cluster with the centrosome, and stabilizes the genome during mitosis; contains one transmembrane domain

0.008

ndm

(Negative director of macropinocytosis)

macropinocytosis suppressor Ndm

Contains a coiled-coil, C-terminal BAR-like domain

0.014

hook

hook family protein

Similar to C. elegans ZYG-12 and mammalian HOOK proteins, which mediate the attachment between the centrosome and the nucleus

0.023

abpD

(Actin Binding Protein)

Actin-binding protein D

Actin binding protein that is developmentally and cAMP-regulated; associates with intracellular membranes

0.086

DDB_G0285767

DDB0347641

Not yet annotated

0.003

DDB_G0346831

DDB0346834

Not yet annotated

0.014