Fig. 2

Alignment of Rab supergroup III domains. The alignment shows the amino acid conservation of three Rab domains: the P-loop, involved in trafficking (green), the Switch I (turquoise) and the Switch II (magenta) important for supporting the binding with other molecules. Downstream of Switch I, four ultra-conserved amino acids are highlighted, named FALK (yellow). The white background indicates changes in amino acid composition during evolution. At the bottom, human representatives of other Rab supergroups are reported to show the absence of FALK