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Table 2 Summary of USP4, USP15 and USP11 interaction partners

From: Evolution of the highly networked deubiquitinating enzymes USP4, USP15, and USP11

Pathway

 

USP4

Ref.

USP15

Ref.

USP11

Ref.

RNA splicing

Lsm2

+

 

+

 

 

Lsm4

+

 

+

 

 

Lsm6

+

 

+

 

 

Mepce

+

 

+

 

 

Naa38

+

 

+

 

 

Ppih

+

 

+

 

 

Prp3

+

[9]

+

 

 

Prp31

+

 

+

 

 

Prp4

+

 

+

 

 

Sart3

+

[9]

+

[10]

 

Tut1

+

 

+

 

 

TGF-β signalling

Tgfbr1

+

[13]

+

[4]

+

[12]

Smad7

 

+

[4]

+

[12]

Smad1

 

+

[4]

 

Smad2

 

+

[4]

 

Smad3

 

+

[4]

 

Smad4

 

+

[4]

 

Smurf1

 

+

 

 

Smurf2

 

+

[4]

 

Bmpr1a

 

+

[81]

 

Tumor suppression

p53

 

 

+

[16]

Mdm2

 

+

[15]

 

Arf-bp1

+

[14]

 

 

Brca2

 

 

+

[18]

Pml

 

 

+

[17]

Notch1

 

+

 

+

 

Rb

+

[82]

 

 

Innate immunity

Keap1

 

+

[83]

+

 

Rig-i

+

[84]

 

 

Trim25

 

+

[85]

 

Trim21

+

[86]

 

 

Rip1

+

[87]

 

 

Tak1

+

[6]

 

 

Traf6

+

[7]

 

 

Traf2

+

[7]

 

 

Ikka

 

 

+

[88]

Ikba

 

+

[8]

+

[89]

Wnt/β-catenin signalling

Apc

 

+

[90]

 

Nlk

+

[5]

 

 

Other

A2ar

+

[91]

 

 

Usp7

 

+

 

+

[92]

  1. Interactors were identified in a mass proteomic analysis by Sowa et al. [2] and those validated by independent, small-scale studies are referenced. Note that these include K48- and K63-linked substrates and possibly non-substrate binding partners. Italicized interactors indicate proteins that have antagonistic roles in the indicated pathway