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Figure 7 | BMC Evolutionary Biology

Figure 7

From: Motif types, motif locations and base composition patterns around the RNA polyadenylation site in microorganisms, plants and animals

Figure 7

Most frequent 20 hexamer motifs in the poly(A) site region in 30499 unique poly(A) sites mapped to the human genome. Order in the peak point labeling: motif sequence, position, and frequency at the single specific position in the mapped poly(A) site regions (pre-mRNA). The AAAAAA motif was the highest at position 1, but the frequencies or AAAAAA and UUUUUU were inflated in counting, for example, a sequence of 8 A’s was counted as three copies of AAAAAA motifs when counting motifs at each position. It is why AAAAAA was not showing in the figure here. The UUUUUU motif listed here was to show the location of the frequency peak. The most abundant five motifs, in terms of the values of the highest peaks were AAUAAA, CAAAAA, UAAAAA, UUAAAA, and AAAUAA. The top five motifs, in terms of the number of accumulated copies along the 201-base region were AAAAAA (135.84%), AAUAAA (75.64%), UUUUUU (73.87%), AAAUAA (46.93%), AUAAAA (41.40%). Note that the most frequent motifs are mainly on three places: the −21 position region (upstream A-rich element; mainly AAUAAA), the poly(A) site, and the downstream U-rich region with peak location approximately at +19. No highly abundant hexanucleotide motifs were detected from other regions.

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