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Figure 3 | BMC Evolutionary Biology

Figure 3

From: Statistical tests for natural selection on regulatory regions based on the strength of transcription factor binding sites

Figure 3

Dependence of the distribution of ΔS on evolutionary parameters. a) shows the probability distribution of ΔS as evolutionary distance varies (coloured solid traces) for the Bcd matrix under an HKY model with transition-transversion rate ratio set to 2. The distribution rapidly converges to the long-time limit distribution (dotted trace). b) shows the probability distribution of ΔS as the transition-transversion rate ratio (kappa) varies (coloured solid traces) for the Bcd matrix under an HKY model with evolutionary distance set equal to 0.3 substitutions per site. Once again, the distribution converges to the long-time limit (dotted trace). Inset in both is the convergence of the mean of ΔS (squares) to the long-time limit (dotted trace). Distributions are for real binding sites evolving in the absence of selection.

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