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Table 2 Domains considered as diagnostic for each protein

From: Origin and evolution of the Notch signalling pathway: an overview from eukaryotic genomes

Proteins Diagnostic domains References
Notch LNR/EGF/ANK [23]
Delta DSL/EGF [23]
Fringe Fringe [80]
Adam 10/17 ZNMc/Disin [139]
Pres Peptidase A22 [140]
Nicastrin M20-dimer superfamily [141]
APH1 APH1 superfamily [63]
PEN2 - [63]
CSL/Su(H) lag1/IPT RBJ Kappa/beta trefoil [142]
MAM Maml - 1 [143]
Numb numbF/PH-like [144]
Sno ABC-ATPase [26]
Neur Neur/Zinc finger Ring [145]
Mib Mib-herc2/ANK/ZF ring/ZZ Mind [28]
Deltex WWE/ZF ring [25]
NEDD4/Su(dx) C2/WW/HECT [146]
Nle NLE/WD40 [72]
Furin subtilisin/proprotein convertase/furin [130]
O-fut - [147]
SMRT SANT [148]
HES HLH/Hairy orange [149]