Table 2 Domains considered as diagnostic for each protein
From: Origin and evolution of the Notch signalling pathway: an overview from eukaryotic genomes
Proteins | Diagnostic domains | References |
|---|---|---|
Notch | LNR/EGF/ANK | [23] |
Delta | DSL/EGF | [23] |
Fringe | Fringe | [80] |
Adam 10/17 | ZNMc/Disin | [139] |
Pres | Peptidase A22 | [140] |
Nicastrin | M20-dimer superfamily | [141] |
APH1 | APH1 superfamily | [63] |
PEN2 | - | [63] |
CSL/Su(H) | lag1/IPT RBJ Kappa/beta trefoil | [142] |
MAM | Maml - 1 | [143] |
Numb | numbF/PH-like | [144] |
Sno | ABC-ATPase | [26] |
Neur | Neur/Zinc finger Ring | [145] |
Mib | Mib-herc2/ANK/ZF ring/ZZ Mind | [28] |
Deltex | WWE/ZF ring | [25] |
NEDD4/Su(dx) | C2/WW/HECT | [146] |
Nle | NLE/WD40 | [72] |
Furin | subtilisin/proprotein convertase/furin | [130] |
O-fut | - | [147] |
SMRT | SANT | [148] |
HES | HLH/Hairy orange | [149] |