Figure 3
From: Evolutionary constraints permeate large metabolic networks
Reaction constraint graphs show many more and smaller constrained reaction sets than randomized graphs. The plots show a) the number of components, b) the mean size of components, and c) the maximum component size (vertical axes), as a function of the negative decadic logarithm of the significance threshold P (horizontal axis), for reaction constraint graphs (closed circles) and randomized versions of these graphs (open circles). Randomization was carried out with an edge swapping algorithm [102] (see Methods) that preserves the graph's degree distribution. All data for random reaction graphs are based on 20 randomized graphs for each significance threshold. Error bars for randomized graphs indicate one standard deviation. Where invisible, standard deviations are too small to be shown. The two graphs drawn above panel a) show the structure of the reaction constraint graph at two significance thresholds, -log10(P) = 9.5 (left) and -log10(P) = 30 (right).