Figure 3

Results of EDAR in the visualization interface. Data are illustrated in three parts as Overview (chromosome scale), Region (area of searching target and flanking sequences), and Details (searching target). The Overview shows the F _ST values of 100 kb sliding windows (maroon) and the low HET regions of merged window outliers in HapMap geographical group of ASN (red), CEU (green), and YRI (blue) along the ideogram of the chromosome. Region image displays the normalized HET values of 100 kb sliding windows that flanking the searching target in each population with the same color as illustrated in Overview. The basic line (zero) represents the average values of Normalized HET, therefore the comparatively high HET windows are shown above zero and low HET windows appear below the basic line. For the Details of the searching target, it provides (from the top to the bottom) the fine position in the chromosome, the low HET region (merged outliers of sliding windows) in the geographical group (red bar for ASN in EDAR gene), the genes (incarnadine) with the arrow pointing to the transcription direction, the transcripts and the frame usage of the genes (grey), the SNP outliers of iHS in each population as colored sticks, and at last the SNP outliers of F _ST (maroon) to demonstrate if differentiation signals exist among three populations. For EDAR gene with a yellow label as the target gene, it is localized in a highly differentiated region among the geographical group and much more iHS outliers are in ASN than that in CEU and YRI groups. In addition, F _ST outliers are also enriched in EDAR.