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Figure 3 | BMC Evolutionary Biology

Figure 3

From: Multiple gains of spliceosomal introns in a superfamily of vertebrate protease inhibitor genes

Figure 3

Intron gain in group V6 during diversification of ray-finned fishes. Ray-finned fishes contain up to three HSP47-related genes basically sharing the intron pattern of group V6 (intron positions marked in red). Non-canonical introns (positions marked in green) are exclusively found in some HSP47-related genes from Oryzias latipes, Gasterosteus aculeatus and Takifugu rubripes, but not in Danio rerio or other members of group V6. An intron located outside the serpin scaffold of X. tropicalis HSP47 is depicted in turquoise. Intron positions of human α1-antitrypsin (A1, group V2) are shown in yellow. The characteristic ER retention signal present at the C-terminus of all members of group V6 is printed in white on blue background. Sequence alignments and intron mapping were accomplished as described in the legend to Figure 2.

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