Skip to main content

Table 2 Predicted affection status for the amino acid substitutions from PRLR gene exon 10

From: Divergent evolution in the cytoplasmic domains of PRLR and GHR genes in Artiodactyla

 

SIFT

PolyPhen

Species

prediction

score

MSC

n

prediction

PSIC±

n

European Cattle (Bos taurus)

       

P340T

tolerated

0.35

3.1

30

benign

0.78

33

E378K

affect protein function

0.02

3.12

28

benign

0.88

27

A536V

tolerated

0.34

3.1

29

benign

0.41

31

African Cattle (Bos indicus)

       

V439M

tolerated

0.07

3.1

29

benign

0.39

31

L497R

tolerated

0.36

3.1

29

benign

0.13

30

American bison (Bison bison)

       

E384K*

tolerated

0.06

3.08

27

benign

1.48

23

European bison (Bison bonasus)

       

E384K*

tolerated

0.06

3.05

29

benign

1.50

22

Q394K*

tolerated

0.16

3.05

29

benign

1.21

24

M445V*

tolerated

0.42

3.05

28

benign

1.48

22

Sheep (Ovis aries)

       

E387K

tolerated

0.47

3.05

29

benign

0.57

31

A476T

tolerated

0.64

3.05

29

benign

0.10

30

S480R

tolerated

0.62

3.05

29

benign

0.24

31

Domestic pig (Sus scrofa)

       

L406P

tolerated

0.25

3.16

27

benign

0.65

23

D428A

tolerated

0.54

3.15

29

benign

0.04

28

A461G

tolerated

0.36

3.15

29

benign

1.34

28

K480R

tolerated

0.61

3.15

29

benign

0.29

28

M510L

tolerated

0.64

3.15

29

benign

1.31

28

G534S

tolerated

0.79

3.17

25

benign

0.23

23

G597S

tolerated

0.65

3.15

25

benign

0.35

18

A601V

tolerated

0.23

3.15

25

benign

0.51

19

  1. * analyses were done using the cytoplasmic part alone, MSC = median sequence conservation, n = number of sequences represent at this position in the protein alignment, ± PSIC score difference