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Figure 7 | BMC Evolutionary Biology

Figure 7

From: Zebrafish RNase T2 genes and the evolution of secretory ribonucleases in animals

Figure 7

Mutations in CAS II of fish RNase T2 proteins. The alignment shows the conserved CAS II region characteristic of RNase T2 enzymes. The absolutely conserved His (black box, white font) is part of the catalytic site of the enzyme. A second His residue (green), possibly involved in substrate binding or stabilization of an intermediate in the catalytic reaction, is mutated in most fish RNases. In the RNase Dre2 clade this His is mutated to Tyr (yellow). In the RNase Dre1 clade the His is mutated to a series of polar amino acids (red). Similar mutations are found in some plant S-RNases (S2 RNase and S3 RNase).

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