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Table 2 HPeV P1 and VP1 substitution rates and TMRCA estimates under a strict and relaxed lognormal molecular clock

From: Rooting human parechovirus evolution in time

Genetic region

Molecular clock

Substitution rate

(× 10-3)a

TMRCAb

Log10 BFc

P1 gene

Strict

2.03 (1.15, 2.91)

1581 (1334 – 1733)

-7.03 ± 0.3

 

Lognormal

2.21 (0.48, 4.21)

1603 (940 – 1883)

0.0

VP1 gene

Strict

2.30 (1.74, 2.90)

1553 (1412 – 1673)

-27.8 ± 0.2

 

Lognormal

2.79 (2.05, 3.66)

1600 (1427 – 1733)

0.0

  1. a The median estimates of the substitution rates and bTMRCA for the P1 and VP1 region are shown for each molecular clock with 95% lower and upper bounds of the highest probability density intervals in parentheses. c The log10 Bayes factor (BF) difference (± standard error) in estimated harmonic median of the marginal likelihoods (with the posterior as distribution probability) compared with the clock model with strongest support. For each dataset the highest -log10 Bayes factor corresponds to the best-fit clock model (highlighted in bold).