From: Diversity and evolution of the small multidrug resistance protein family
 |  |  | SMR association to the following operons | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
 |  |  |  | Amino Acid Transport/Metabolism | Multidrug Resistance | Lipid Mtabolism | |||||
SMR Subclass | Subclass Member | Total number of Loci |  | Lys/Arg | Trp/Tyr/Phe | Other Amino Acids | Polyamine (spe/cad/put) & Betaine | Glyco-peptide & Poly-ketide | β-lactam metabolism | Sn-G3P | Fatty Acid synthesis |
SUG | sugE | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Putative operons | Â | 118 | Â | lys | trp/aro | liv/ilv/pro | put/spe/bet | MFS/ABC/ecn/bleo | tetR/pbp | ugp/pls | fab/acc |
Frequency in operon/total surveyed loci | Â | Â | Â | 0.8% | 4.2% | 1.7%/0.8%/0.8% | 0.8%/1.7%/0.8% | 3.4%/2.5%/3.4%/0.8% | 5.1%/0.8% | 0.8%/2.5% | 1.7%/0.8% |
Frequency of occurrence in each locus (10 gene radius) | Â | Â | Â | 29.7% | 20.3% | 2.0% | 5.1% | 22.9% | 23.7% | 7.6% | 17.8% |
SMP | emrE/smr | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Putative operons | Â | 92 | Â | lys | tyr | pro/his/met/cys | put/bet/dpp | ABC/bleo/hlx | tetR/pbp | glp | fab/ech |
Frequency in operon/total surveyed loci | Â | Â | Â | 1.1% | 1.1% | 1.1%/1.1%/1.1%/2.2% | 1.1%/3.3%/1.1% | 1.1%/1.1%/2.2% | 8.7%/1.1% | 3.3% | 1.1%/2.2% |
Frequency of occurrence in each locus (10 gene radius) | Â | Â | Â | 22.8% | 14.1% | 12.0% | 14.1% | 28.3% | 10.9% | 9.8% | 22.8% |
PSMR | yvaE** | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Putative operons | Â | 16 | Â | --- | --- | pro | --- | MFS/ABC | tetR | --- | acp/fab |
Frequency in operon/total surveyed loci | Â | Â | Â | --- | --- | 12.5% | --- | 6.3%/18.8% | 1.1% | --- | 12.5%/6.3% |
Frequency of occurrence in each locus (10 gene radius) | Â | Â | Â | 25.0% | Â | 18.8% | --- | 43.8% | 12.5% | 6.3% | 18.8% |
PSMR | yvaD** | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Putative operons | Â | 7 | Â | arg | --- | --- | --- | --- | tetR | --- | acp/fab |
Frequency in operon/total surveyed loci | Â | Â | Â | 14.3% | --- | --- | --- | --- | 14.3% | --- | 28.6% |
Frequency of occurrence in each locus (10 gene radius) | Â | Â | Â | 14.3% | --- | --- | --- | --- | 28.6% | --- | 42.9% |
PSMR | ydgE/ydgF | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Putative operons | Â | 22 | Â | lysR | --- | --- | spe* | --- | --- | --- | --- |
Frequency in operon/total surveyed loci | Â | Â | Â | 4.5% | --- | --- | --- | --- | --- | --- | --- |
Frequency of occurrence in each locus (10 gene radius) | Â | Â | Â | 54.5% | --- | --- | 31.8% | 22.7% | --- | --- | 22.7% |
PSMR | ebrA/ebrB | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Putative operons | Â | 16 | Â | --- | --- | --- | --- | --- | --- | --- | --- |
Frequency in operon/total surveyed loci | Â | Â | Â | --- | --- | --- | --- | --- | --- | --- | --- |
Frequency of occurrence in each locus (10 gene radius) | Â | Â | Â | 12.5% | 6.3% | --- | 6.3% | 31.3% | 43.8% | --- | 50.0% |
PSMR | ykkC/ykkD | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Putative operons | Â | 9 | Â | --- | aro | liv | spe | MFS | --- | --- | --- |
Frequency in operon/total surveyed loci | Â | Â | Â | --- | 11.1% | 11.1% | 11.1% | 11.1% | --- | --- | --- |
Frequency of occurrence in each locus (10 gene radius) | Â | Â | Â | 22.2% | 55.6% | 11.1% | 11.1% | 33.3% | 33.3% | 11.1% | 44.4% |
PSMR | yvdR/yvdS | 3 | Â | NA | NA | NA | NA | NA | NA | NA | NA |
Total loci | Â | 283 | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 |  |  | SMR association to the following operons | ||||||||
 |  |  | Vitamin Metabolism | Nucleotide Metabolism | Horizontal Gene Transfer System | ||||||
SMR Subclass | Subclass Member | Total number of Loci | Vitamin (Vit.) B1, B2, & BB3 (thi, rib, nia) | Vit. B7 & BB9 (bio/fol) | Vit. B6 & BB12 (Pyd & Cob) | Coenz. Q10 (Ubi) & F420 | Pur | Pyr | Int/Tn/Mat | Plasmid | Phage genes |
SUG | sugE | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Putative operons | Â | 118 | thi/nad | fol | --- | ubi | pur | ctp | tn/rve | vap/kill | --- |
Frequency in operon/total surveyed loci | Â | Â | 0.8/2.5% | 0.8% | --- | 1.7% | 4.2% | 0.8% | 2.5% | 2.5% | --- |
Frequency of occurrence in each locus (10 gene radius) | Â | Â | 7.6% | 1.7% | 2.5% | 11.9% | 22.0% | 3.4% | 21.2% | 9.3% | 5.9% |
SMP | emrE/smr | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Putative operons | Â | 92 | thi/nad | bio/fol | cob | --- | pur | --- | tn/rve | --- | Pro-phage DLP12 |
Frequency in operon/total surveyed loci | Â | Â | 1.1%/1.1% | 1.1%/1.1% | 2.2% | --- | 1.1% | --- | 3.3% | --- | 1.1% |
Frequency of occurrence in each locus (10 gene radius) | Â | Â | 17.4% | 12.0% | 3.3% | 9.8% | 8.7% | 3.3% | 14.1% | 2.2% | 4.3% |
PSMR | yvaE** | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Putative operons | Â | 16 | --- | --- | --- | --- | --- | --- | --- | --- | --- |
Frequency in operon/total surveyed loci | Â | Â | --- | --- | --- | --- | --- | --- | --- | --- | --- |
Frequency of occurrence in each locus (10 gene radius) | Â | Â | --- | 6.3% | --- | 25.0% | --- | --- | 12.5% | --- | --- |
PSMR | yvaD** | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Putative operons | Â | 7 | --- | --- | --- | ubi | pur | --- | --- | --- | --- |
Frequency in operon/total surveyed loci | Â | Â | --- | --- | --- | 28.6% | 14.3% | --- | --- | --- | --- |
Frequency of occurrence in each locus (10 gene radius) | Â | Â | --- | 14.3% | --- | 42.9% | 42.9% | 28.6% | 14.3% | --- | --- |
PSMR | ydgE/ydgF | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Putative operons | Â | 22 | --- | --- | --- | --- | --- | --- | tn/rve | tra/cop | --- |
Frequency in operon/total surveyed loci | Â | Â | --- | --- | --- | --- | --- | --- | 4.5% | 9.1% | --- |
Frequency of occurrence in each locus (10 gene radius) | Â | Â | 13.6% | 18.2% | --- | --- | 18.2% | 4.5% | 9.1% | 9.1% | 13.6% |
PSMR | ebrA/ebrB | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Putative operons | Â | 16 | nad* | fol | --- | --- | pur | --- | --- | --- | --- |
Frequency in operon/total surveyed loci | Â | Â | 12.5% | 6.3% | --- | --- | 6.3% | --- | --- | --- | --- |
Frequency of occurrence in each locus (10 gene radius) | Â | Â | 18.8% | 25.0% | 12.5% | 6.3% | 25.0% | --- | 25.0% | --- | 6.3% |
PSMR | ykkC/ykkD | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Putative operons | Â | 9 | rib | bio | --- | --- | pur | pyr | --- | cdt | --- |
Frequency in operon/total surveyed loci | Â | Â | 11.1% | 11.1% | --- | --- | 22.2% | 11.1% | --- | 11.1% | --- |
Frequency of occurrence in each locus (10 gene radius) | Â | Â | 22.2% | 11.1% | 11.1% | --- | 33.3% | 11.1% | 11.1% | 11.1% | --- |
PSMR | yvdR/yvdS | 3 | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Total loci | Â | 283 | Â | Â | Â | Â | Â | Â | Â | Â | Â |