Table 1 List of the 81 ICDSs common to M. tuberculosis H37Rv, CDC1551, M. bovis AF2122/97 and M. africanum GM041182.
M. tub H37Rv | M. tub CDC1551 | M. bov AF2122/97 | M. bov BCG 1173P2 | M. africanum | Putative function | Functional classification |
0002 (Rv0151c 588 aa) | 0004 | 0006 | 0109 | ICDS | PE family protein | PE/PPE |
0003 (Rv0152c 525 aa) | 0005 | 0007 | 0004 | ICDS | PE family protein | PE/PPE |
0007 (Rv0366c 197 aa – Rv0367c 129 aa) | 0011 | 0010 | 0110 | ICDS | Conserved hypothetical | Unknown |
0009 (Rv0393 441 aa) | 0012 | 0011 | 0008 | ICDS | Conserved hypothetical | Unknown |
0010 (Rv0520 116 aa – Rv0521 101 aa) | 0014 | 0013 | 0012 | ICDS | Dimethylglycine N-methyltransferase | Intermediary metabolism |
0012 (Rv0601c 157 aa) | 0017 | 0018 | 0016 | ICDS° | Two-component sensor kinase | Regulation |
0014 (Rv0635 158 aa – Rv0636 142 aa) | 0019 | 0020 | 0111 | ICDS | Conserved hypothetical | Unknown |
0015 (Rv0636 142 aa – Rv0637 166 aa) | 0020 | 0021 | 0112 | ICDS | Conserved hypothetical | Unknown |
0017 (Rv0724A 112 aa – Rv0725c 301 aa) | 0022 | 0023 | 0020 | ICDS | Conserved hypothetical | Unknown |
0020 (Rv0865 160 aa) | 0026 | 0085 | 0113 | ICDS | Molybdopterin biosynthesis protein | Intermediary metabolism |
0021 (Rv0890c 882 aa – Rv0891c 285 aa) | 0027 | 0025 | 0114 | ICDS | Transcriptional regulator | Regulation |
0023 (Rv1034c 130 aa – Rv1035c 228 aa) | 0030 | 0030 | 0031 | ICDS | Transposase | IS/phage |
0024 (Rv1035c 228 aa – Rv1036c 112 aa) | 0031 | 0031 | 0032 | ICDS | Transposase | IS/phage |
0025 (Rv1041c 287 aa – Rv1042c 135 aa) | 0032 | 0086 | 0034 | ICDS | Transposase | IS/phage |
0026 (Rv1104 229 aa) | 0034 | 0087 | 0115 | ICDS | Esterase | Intermediary metabolism |
0027 (Rv1104 229 aa) | 0035 | 0088 | 0037 | ICDS | Esterase | Intermediary metabolism |
0028 (Rv1105 171 aa) | 0036 | 0033 | 0036 | ICDS | Para-nitrobenzyl esterase | Intermediary metabolism |
0029 (Rv1119c 49 aa - Rv1120c 164 aa) | 0037 | 0034 | 0039 | ICDS | Conserved hypothetical | Unknown |
0030 (Rv1136 113 aa) | 0039 | 0089 | 0040 | ICDS | Enoyl-CoA | Lipid metabolism |
0032 (Rv1149 135 aa – Rv1150 183 aa) | 0041 | 0090 | 0041 | ICDS | Transposase | IS/phage |
0033 (Rv1163 201 aa – Rv1164 246 aa) | 0042 | 0035 | 0116 | ICDS | Nitrate reductase NarI-J | Intermediary metabolism |
0035 (Rv1203c 194 aa – Rv1204c 562 aa) | 0044 | 0036 | 0043 | ICDS | Conserved hypothetical | Unknown |
0036 (Rv1413 171 aa) | 0046 | 0041 | 0047 | ICDS | Conserved hypothetical | Unknown |
0040 (Rv1662 1602 aa – Rv1663 502 aa) | 0053 | 0043 | 0117 | ICDS | Polyketide synthase Pks8/17 | Lipid metabolism |
0041 (Rv1687c 255 aa) | 0054 | 0132 | 0128 | ICDS° | ATP binding protein, ABC transporter | Cell wall, process |
0043 (Rv1735c 166 aa) | 0056 | 0112 | 0050 | ICDS | Malic acid transport protein | Cell wall, process |
0046 (Rv1878 450 aa) | 0061 | 0052 | 0118 | ICDS° | Glutamine synthetase GlnA3 | Intermediary metabolism |
0047 (Rv1888A 58 aa – Rv1889c 118 aa) | 0062 | 0053 | 0119 | ICDS | Conserved hypothetical | Unknown |
0048 (Rv1931c 259 aa) | 0064 | 0054 | 0058 | ICDS | Conserved hypothetical | Unknown |
0049 (Rv1949c 319 aa – Rv1950c 63 aa) | 0065 | 0055 | 0059 | ICDS | Conserved hypothetical | Unknown |
0050 (Rv2013 159 aa – Rv2014 196 aa) | 0066 | 0056 | 0061 | ICDS° | Transposase | IS/phage |
0051 (Rv2086 201 aa) | 0067 | 0093 | 0062 | ICDS | Conserved hypothetical | Unknown |
0052 (Rv2086 201 aa – Rv2087 76 aa) | 0068 | 0058 | 0063 | ICDS | Conserved hypothetical | Unknown |
0053 (Rv2087 76 aa) | 0069 | 0094 | 0064 | ICDS | Conserved hypothetical | Unknown |
0054 (Rv2095c 316 aa – Rv2096 332 aa) | 0070 | 0133 | 0129 | ICDS | Conserved hypothetical | Unknown |
0058 (Rv2321 182 aa – Rv2322c 221 aa) | 0074 | 0060 | 0067 | ICDS | Ornithine aminotransferase RocD1 | Intermediary metabolism |
0059 (Rv2325 282 aa – Rv2326c 697 aa) | 0075 | 0096 | 0120 | ICDS | Conserved hypothetical | Unknown |
0060 (Rv2331 129 aa) | 0076 | 0134 | 0130 | ICDS | Hypothetical | Unknown |
0061 (Rv2337 372 aa – Rv2338c 318 aa) | 0077 | 0097 | 0068 | ICDS | Conserved hypothetical | Unknown |
0062 | 0081 | 0065 | 0076 | ICDS | Hydrogenase nickel incorporation protein HypB | Intermediary metabolism |
0063 (Rv2877c 287 aa – Rv2878c 173 aa) | 0082 | 0099 | 0077 | ICDS° | Conserved hypothetical | Unknown |
0065 (Rv2943A 177 aa – Rv2944 239 aa) | 0083 | 0066 | 0079 | ICDS | Transposase | IS/phage |
0068 (Rv3128c 338 aa) | 0088 | 0068 | 0082 | ICDS | Conserved hypothetical | Unknown |
0069 (Rv3152 410 aa – Rv3153 211 aa) | 0089 | 0100 | 0121 | ICDS | NADH dehydrogenase I | Intermediary metabolism |
0070 (Rv3172c 160 aa) | 0090 | 0069 | 0083 | ICDS | Conserved hypothetical | Unknown |
0071 (Rv3200c 355 aa) | 0091 | 0101 | 0122 | ICDS | Hypothetical | Unknown |
0075 (Rv3349c 246 aa) | 0100 | 0102 | 0085 | ICDS° | Transposase | IS/phage |
0076 (Rv3351c 264 aa – Rv3352c 123 aa) | 0101 | 0071 | 0088 | ICDS | Oxidoreductase | Intermediary metabolism |
0077 (Rv3352c 123 aa – Rv3353c 86 aa) | 0102 | 0072 | 0089 | ICDS | Oxidoreductase | Intermediary metabolism |
0079 (Rv3419c 344 aa) | 0104 | 0135 | 0131 | ICDS | O-sialoglycoprotein endopeptidase | Intermediary metabolism |
0080 (Rv3420c 158 aa – Rv3421c 211 aa) | 0105 | 0104 | 0092 | ICDS° | Conserved hypothetical | Unknown |
0083 | 0108 | 0107 | 0095 | ICDS | Transposase | IS/phage |
0084 (Rv3636 115 aa – Rv3637 166 aa) | 0111 | 0076 | 0097 | ICDS | Transposase | IS/phage |
0087 (Rv3741c 224 aa – Rv3742c 131 aa) | 0114 | 0078 | 0099 | ICDS° | Aromatic-ring hydroxylase | Intermediary metabolism |
0088 (Rv3770A 61 aa – Rv3770B 64 aa) | 0115 | 0079 | 0100 | ICDS° | Transposase | IS/phage |
0089 (Rv 3844 164 aa – Rv3845 120 aa) | 0116 | 0136 | 0132 | ICDS | Transposase | IS/phage |
0090 (Rv3866 283 aa – Rv3867 183 aa) | 0117 | 0109 | 0123 | ICDS | Conserved hypothetical | Unknown |
0091 (Rv3880c 115 aa – Rv3881 460 aa) | 0118 | 0137 | 0133 | ICDS | Conserved hypothetical | Unknown |
0095 (Rv3900c 311 aa) | 0122 | 0083 | 0124 | ICDS | Conserved hypothetical | Unknown |
0097 (Rv3913 335 aa – Rv3914 116 aa) | 0123 | 0111 | 0001 | ICDS | Thioredoxin reductase | Intermediary metabolism |
0098 | 0124 | 0032 | 0035 | ICDS | Conserved hypothetical | Unknown |
0099 (Rv3386 234 aa – Rv3387 225 aa) | 0125 | 0103 | 0090 | ICDS | Transposase | IS/phage |
0100 (Rv0342 640 aa – Rv0343 493 aa) | 0126 | 0009 | 0125 | ICDS | Isoniazid inductible gene protein | Cell wall, process |
0101 (Rv0763c 69 aa – Rv0764c 451 aa) | 0127 | 0084 | 0126 | ICDS | Cytochrome P450 | Intermediary metabolism |
0102 (Rv1858 264 aa – Rv1859 369 aa) | 0128 | 0092 | 0127 | ICDS | Molybdenum transport ABC transporter | Cell wall, process |
0103 (Rv0449c 439 aa) | 0129 | 0113 | 0010 | ICDS | Conserved hypothetical | Unknown |
0104 (Rv0471c 162 aa) | 0130 | 0114 | 0011 | ICDS | Hypothetical | Unknown |
0105 (Rv0859 403 aa – Rv0860 720 aa) | 0131 | 0115 | 0024 | ICDS° | Acyl-CoA thiolase FadA and dehydrogenase FadB | Lipid metabolism |
0106 (Rv0880 143 aa – Rv0881 288 aa) | 0132 | 0116 | 0025 | ICDS° | Transcriptional regulator | Information pathway |
0107 (Rv0997 143 aa) | 0133 | 0117 | 0029 | ICDS | Hypothetical | Unknown |
0108 (Rv1041c 287 aa – Rv1042c 135 aa) | 0134 | 0118 | 0033 | ICDS° | Transposase | IS/phage |
0109 (Rv1104 229 aa – Rv1105 171 aa) | 0135 | 0119 | 0038 | ICDS | Para-nitrobenzyl esterase | Intermediary metabolism |
0110 (Rv1221 257 aa – Rv1222 154 aa) | 0136 | 0120 | 0044 | ICDS | Alternative sigma factor SigE | Information pathway |
0111 (Rv1752c 149 aa) | 0137 | 0121 | 0051 | ICDS | Conserved hypothetical | Unknown |
0112 (Rv1961 164 aa) | 0138 | 0122 | 0060 | ICDS | Hypothetical | Unknown |
0113 (Rv2309c 151 aa) | 0139 | 0123 | 0066 | ICDS | Integrase | Information pathway |
0114 (Rv2420c 127 aa – Rv2421c 211 aa) | 0140 | 0124 | 0070 | ICDS | nicotinate-nucleotide adenylyltransferase NadD | Intermediary metabolism |
0115 (Rv2732c 205 aa – Rv2733c 512 aa) | 0141 | 0125 | 0073 | ICDS | Conserved hypothetical | Unknown |
0116 (Rv2922A 94 aa – Rv2923c 137 aa) | 0142 | 0126 | 0078 | ICDS | Acylphosphatase AcyP | Intermediary metabolism |
0117 (Rv3774 274 aa – Rv3775 274 aa) | 0143 | 0127 | 0101 | ICDS° | Enoyl-CoA hydratase EchA21 and lipase LipE | Lipid metabolism |
0119 (Rv2599 143 aa – Rv2600 133 aa) | 0144 | 0098 | 0134 | ICDS° | Conserved hypothetical | Unknown |