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Table 1 Core Conserved Protein Families

From: Identification of multiple independent horizontal gene transfers into poxviruses using a comparative genomics approach

Vaccinia Gene

Putative Function

A2L

Transcription factor VLTF

A3L

Viral core protein p4b

A7L

Subunit of VETF (82 kDa)

A10L

Virion core protein p4a

A11R

Virion formation

A16L

Myristylated protein/membrane protein

A18R

DNA helicase/transcriptional elongation factor

A22R

Holliday junction endonuclease/palmitylprotein

A23R

Subunit of VITF-3 (45 kDa)

A24R

RNA polymerase subunit rpol 32

A32L

ATPase/DNA packaging/virion assembly

D5R

NTPase

D6R

Subunit of VETF (70 kDa)

D11L

ATPase/nucleoside triphosphate phosphohydrolase/transcription termination factor

D12L

Subunit of mRNA capping enzyme/transcription termination factor

E1L

Poly A polymerase subunit

E6R

Hypothetical protein

E9L

DNA polymerase

E10R

Sulfhydryl oxidase/redox protein/S-S bond formation/virus assembly

F9L

Membrane protein/S-S bond formation pathway protein

F10L

Serine/threonine kinase

G5R

Ribonucleotide reductase/morphogenesis

G7L

Structural virion core protein

G9R

Myristylated protein/membrane protein

H2R

Late protein

H6R

DNA topoisomerase

I7L

Virion core cysteine protease

I8R

RNA helicase

J3R

Poly A polymerase subunite/cap methyltransferase

J5L

Membrane protein

J6R

RNA polymerase subunit

L1R

ImV envelope/membrane protein

L3L

Hypothetical protein