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Figure 3 | BMC Evolutionary Biology

Figure 3

From: Module evolution and substrate specificity of fungal nonribosomal peptide synthetases involved in siderophore biosynthesis

Figure 3

Maximum likelihood tree of all AMP domains examined in this study demonstrating two separate lineages of ferrichrome synthase NRPSs. N-terminal A domains of both lineages group together and C-terminal domains of both lineages group together (thick vertical bars). NPS2, module 2 groups with the C-terminal modules, while NPS1/SidC module 2 and Dothideomycete NPS2 module D.3 group with the N-terminal modules. Numbered nodes indicate duplications inferred from the reconciliation analysis. White circles indicate a duplication inferred due to incongruence of the gene tree with the species tree (see Additional files 2 and 6), while red circles indicate a duplication inferred due to the presence of two copies of a gene in the same species. Bootstrap support values greater than 50% are reported above branches. Note that the A domains of SidE module 1 group as directly sister to all ferrichrome synthetase A domains examined here, while A domains of SidE module 2 group with A domains of other types of C. heterostrophus NRPSs. For species and protein Accession numbers see Additional file 1. Nomenclature: e.g., Ch_ NPS2_AAX09984_AMP3_4 indicates C. heterostrophus, protein accession number AAX09984, AMP module 3 of a total of 4 (see Fig. 2). For Bayesian analysis, see Additional files 3 and 6.

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