Figure 5

A multiple PIP alignment of mouse, tammar, and chicken intron 10 against human (A). There are many areas of high conservation (red) and homology (green) between human and mouse, but little with tammar and chicken. The transcription start site (TSS) of KCNQ1OT1 is indicated by a blue arrow. Although the TSS is not highly conserved between mouse and human, the upstream promoter region is, as is the position of the CpG island relative to the TSS (B.). Although mouse and human have a similar numbers and types of repetitive elements, only the L1MB element upstream of the TSS may be conserved. In tammar, as in other regions, there are fewer DNA elements (pink) and LTR elements (purple) compared to human and mouse. Simple repeats (green) and non-LTR (LINE/SINEs, blue) are similar in human, mouse and tammar, but significantly fewer in chicken.