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Figure 3 | BMC Evolutionary Biology

Figure 3

From: In silico identification of functional divergence between the multiple groEL gene paralogs in Chlamydiae

Figure 3

Coevolution analyses of GroEL proteins with known protein clients for Escherichia coli GroEL. We built ten MIC categories and calculated the percentage of pairs showing significant coevolution within each category (number of pairs in that MIC category divided by the total number of coevolving pairs for the comparison) in each comparison. We estimated the mean percentage of pairs per MIC category and comparison and compared the sets of data. A) Mean MIC values resulted from coevolution analyses of GroEL1 with the different protein clients (black bars), was compared to those MIC values for GroEL2 vs protein clients (grey bars) and GroEL3 vs protein clients (white bars). To better account for the distribution of MIC values in each set of coevolutionary analyses, we multiplied the % of pairs of coevolving sites in each category per 100 and per the Mean MIC value for that category and normalised the mean values obtained for all the categories in each GroEL set of comparisons as to determine the increment of coevolution between the GroEL copies and GroEL clients (B).

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