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Table 3 Core metazoan metzincins and deuterostome innovations.

From: The evolution of the vertebrate metzincins; insights from Ciona intestinalis and Danio rerio

Gene family

Ancestral protostome*

Ciona

Human

Zebrafish

ADAM

3

3

21

22

ADAMTS

5

7

25

27

BMP1/TLL

1

1

3

4

Meprin

0

0

2

4

MMP

2

5

25

26

TIMP

1

1

4

4

  1. The number of genes present in the ancestral protostomes and chordate lineages are displayed for their respective gene family. * Ancestral Protostome content is the representative gene content based on Drosophila melanogaster, Apis mellifera, Anopheles gambiae and Caenorhabditis elegans genomes.