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Figure 2 | BMC Evolutionary Biology

Figure 2

From: The evolution of the vertebrate metzincins; insights from Ciona intestinalis and Danio rerio

Figure 2

Phylogenetic relationships of the ADAM gene family. The ADAM gene family was separated into three sub-analyses, indicated A, B and C, based upon the clades produced and independent phylogenetic analyses performed. The trees shown were inferred by Neighbor Joining from a gapped alignment. The values on the tree nodes are neighbor joining percentage bootstrap values (black), maximum parsimony bootstrap values (blue) and Bayesian clade credibility values (brown). Nodes also present in the tree generated by Maximum Likelihood are indicated (*). The trees are mid-point rooted. The scale bar corresponds to 0.1 amino acid replacements per site (horizontal axis). Where both mouse and human orthologues are present only the human gene is shown. † There is no mouse ADAM20. Ψ D. rerio ADAM12b and ADAM12c group with ADAM12a (Fig. S3). Ω D.rerio ADAML genes based on location in Fig. S1. The full phylogenetic guide tree is available in Fig. S1. The full phylogenetic trees for the A, B and C subgroups, containing all mouse ADAM orthologues, are presented in Figs. S2-S4. Accession numbers for used in the analyses can be obtained from additional file 1. Further analysis on individual sub-fragments of the B-clade, indicated in Fig. S3, found zebrafish ADAM19b (LOC571252) to group with H. sapiens ADAM19 at α; zebrafish ADAM12b (LOC558872) and ADAM12c (LOC561244) to group with D. rerio ADAM12A at β and zebrafish ADAM9 (zgc101824) at χ.

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