Table 2 Comparison of TE insertions between the xenobiotic-metabolizing and ecdysone-synthesizing P450 genes in Drosophila melanogaster
Gene or gene cluster | Function | TE insertion and location* |
|---|---|---|
CYP6A2 | DDT resistance [28-30] | Isfun-1-Dfun-like, 721-bp upstream |
CYP6A8 | DDT resistance [28] | Max, 255-bp upstream |
CYP6A9 | DDT resistance [29] | No |
CYP6G1 | DDT, lufenuron and neonicotinoid resistance [31-33] | Accord, 300-bp upstream of the transcription start site. |
CYP6W1 | DDT resistance [30] | Two INE-1 copies, one 1174-bp upstream, the other 1842 downstream. Further downstream are two 1360, seven INE-1, one Tc1-2, one INE-1, and one mimi-me-Dpse-like. |
CYP4E2 | DDT resistance [27] | Isfun-1-Dfun-like, 707-bp upstream, jockey2, 2274-bp downstream, and Isfun-1-Dfun-like, 2854-bp downstream. |
CYP12A4 | lufenuron resistance [34] | Bari1, 15-bp within the 3' end. |
CYP12D1 | DDT resistance [35, 36] | Two pogo copies, one 8551-bp upstream, the other 98716-bp downstream. |
GSTD1 | DDT dehydrochlorinase activity and DDT resistance [73]. | INE-1, 2191-bp upstream |
CYP302A1 | Ecdysone biosynthesis [37, 38] | No |
CYP306A1 | Ecdysone biosynthesis [39] | No |
CYP307A1 | Ecdysone biosynthesis [40] | No |
CYP314A1 | Ecdysone biosynthesis [18] | No |
CYP315A1 | Ecdysone biosynthesis [38] | No |