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Table 5 Correlation analysis results for the MAP data set.

From: Detecting groups of coevolving positions in a molecule: a clustering approach

PDB

Size

Weight

Stat.

Nmin

p-value

FDR

3D dist.

3D p-value

ARG147, ASP187

2

Unweighted

0.57

4.92

0***

yes

6.24

0.001***

ARG147, ASP187

2

Grantham

0.59

517.54

0***

yes

6.24

0.001***

ARG147, ASP187

2

Volume

0.58

384.76

3e-04***

yes

6.24

0.001***

GLN154, GLU158

2

Unweighted

0.65

4.93

0***

yes

5.96

0.001***‡

GLN154, GLU158

2

Charge

0.67

4.1

1e-04***

yes

5.96

0.001***‡

GLY122, LEU230

2

Unweighted

0.6

6.42

1e-04***

yes

7.44

0.002**‡

GLY122, LEU230

2

Grantham

0.6

590.32

1e-04***

yes

7.44

0.002**‡

GLY122, LEU230

2

Polarity

0.61

18.34

1e-04***

yes

7.44

0.002**‡

GLY122, LEU230

2

Volume

0.48

275.16

0.0052**

yes

7.44

0.002**‡

ALA21, LEU25, GLY107

3

Unweighted

0.45

4.09

1e-04***

yes

12.07

0.001***

LEU25, GLY107

2

Grantham

0.52

312.81

0.0077**

no

12.07

0.031*

THR241, GLY244

2

Unweighted

0.57

3.24

3e-04***

yes

5.11

0.001***

ASN46, SER68

2

Unweighted

0.48

4.67

5e-04***

yes

5.92

0.001***

GLY210, THR225

2

Unweighted

0.56

3.25

5e-04***

yes

8.28

0.004**

ASP219, TRP221, THR222, THR225, ASP227, GLU235, ILE238, THR241, LEU248

9

Grantham

0.3

68.81

6e-04***

yes

40.12

0.2338†

TRP221, THR222

2

Unweighted

0.57

2.73

0.0014**

yes

3.75

0.001***†

TRP221, THR225,

3

Volume

0.56

105.03

0.0092**

no

18.13

0.024*†

ASP227

        

LEU125, THR129

2

Unweighted

0.53

3.21

6e-04***

yes

6.12

0.001***

ASN208, SER231

2

Unweighted

0.48

4.32

7e-04***

yes

4.25

0.001***

TRP221, THR222, ALA232, GLU235, ILE238, VAL239, THR241, ILE247, LEU248

9

Polarity

0.28

2.15

0.001***

yes

34.73

0.025*

GLU148, GLU190

2

Unweighted

0.48

5.11

0.0011**

yes

11.88

0.03*

GLU148, GLU190

2

Polarity

0.5

13.91

0.006**

yes

11.88

0.03*

GLY210, GLY244, GLU246

3

Grantham

0.43

302.15

0.0012**

yes

33.45

0.4945

CYS78, ASN95, SER110, GLY150, GLN233

5

Unweighted

0.24

2.48

0.0018**

yes

21.37

0.001***

CYS169, GLN182

2

Unweighted

0.45

4.39

0.0018**

yes

6.4

0.002**

ILE96, TYR134

2

Unweighted

0.49

5.96

0.002**

yes

18.27

0.1768

ILE81, PHE113

2

Unweighted

0.45

4.33

0.0021**

yes

16.36

0.1259

ASP227, ALA232, GLU235

3

Unweighted

0.48

1.41

0.0022**

yes

23.49

0.0949.

ASP219, VAL223

2

Unweighted

0.46

3.66

0.0024**

yes

9.4

0.009**

HIS63, ARG127, GLN130, ALA209

4

Volume

0.33

205.12

0.0032**

yes

32.09

0.2527

HIS63, GLN130

2

Charge

0.47

5.36

0.0035**

yes

28.75

0.5994

THR222, SER231, ILE238, VAL239

4

Charge

0.71

0.99

0.0039**

yes

28.93

0.1199

ARG124, GLU131

2

Grantham

0.48

461.88

0.0043**

yes

10.6

0.016*

GLU131, VAL157, VAL164

3

Unweighted

0.36

4.39

0.0045**

yes

13.43

0.001***

GLN53, VAL98

2

Grantham

0.48

409.37

0.0049**

yes

13.51

0.0579.

GLU29, VAL32, ILE81, PRO82, THR129, ALA136, ILE149, GLY150, SER163

9

Polarity

0.21

0.1

0.005**

yes

32.31

0.008**

LEU135, PHE156

2

Grantham

0.49

575.88

0.0052**

yes

8.71

0.004**

GLN53, GLU160

2

Charge

0.44

5.85

0.0055**

yes

39.55

0.9311

VAL56, ILE101

2

Unweighted

0.51

6.53

0.0062**

yes

5.28

0.001***

VAL56, ILE101

2

Grantham

0.47

457.69

0.0069**

no

5.28

0.001***

LYS117, GLU123, ARG127

3

Grantham

0.4

487.3

0.0076**

no

15.43

0.004**

PRO118, THR119

2

Polarity

0.47

18.47

0.0096**

no

3.75

0.001***

ALA232, TYR234, GLU235

3

Charge

0.87

1.41

0.0098**

yes

10.51

0.002**

  1. Legends are the same as in table 1. Only groups with a p-value lower than 1% are reported. A global false discovery rate (FDR) of 1% was used when correcting for multiple testing.