Figure 2

Multiple sequence alignment for homologs to fly Dscam exons 4 (panel A), 9 (panel B), and 17 (panel C). Representative sequences from fly, mosquito and honeybee Dscam exon arrays are aligned with homologous sequences from eight vertebrate genomes. Shaded areas indicate columns whose residues produced gaps within the alignment and were excluded from further phylogenetic analyses as discussed in the Methods section. Boxed residues distinguish mammalian Dscam and Dscam-like sequences.