Figure 2
From: Evolution of secretin family GPCR members in the metazoa
Phylogenetic relationship of the metazoan family 2 GPCRs. Consensus phylogenetic tree (neighbour joining method, pairwise gap deletion, Poisson correction distance and 1000 bootstraps) produced with family 2 GPCR TM domains (TM2, TM4, TM5 and TM6). The protostome (nematodes and arthropods) and tunicate (Ciona) receptors are underlined and the bootstrap values for each fork is indicated. Bootstrap values less than 50 were removed. Annotation of the receptor subfamilies was carried out according to Donnelly (1997) [13]. The human (Hsa), Takifugu (Tru), nematodes, C. elegans (Cel) and C. briggsae (Cbr), arthropod D. melanogaster (Dme) and A. gambiae (Aga) and Ciona (Cin) receptor sequences were obtained as described in the methods section.