Data set

2ΔlnL

df

Pvalue

Proportion of sites with ω > 1 (average ω for these sites)

Positively selected codons^{a}


All NAT coding sequences ( n = 43)
     
M1a vs. M2a

0

2

P = 1.0

none
 
M7 vs. M8

3.49

2

P = 0.17

none
 
M0 vs. free ratios

114.89

80

P = 0.006
  
Orthologous sequences to human NAT1 ( n = 19)
     
M1a vs. M2a

0

2

P = 1.0

none
 
M7 vs. M8

0

2

P = 1.0

none
 
M0 vs. free ratios

49.09

34

P = 0.04
  
Orthologous sequences to human NAT2 ( n = 19)
     
M1a vs. M2a

8.48

2

P = 0.01

0.038 (ω = 4.8)
 
M7 vs. M8

11.24

2

P = 0.004

0.041 (ω = 4.6)

191*, 173*

M0 vs. free ratios

27.52

34

P = 0.77
  
 n, number of sequences; 2ΔlnL, twice the loglikelihood difference of the models compared; df, degrees of freedom; Pvalue, level of significance (Pvalues < 0.05 are shown in bold).
 ^{a} Sites pinpointed to be under positive selection under the selection model with the highest likelihood (M8 for the set of NAT2 orthologous sequences) by Bayes Empirical Bayes (BEB) analysis. Only sites with posterior probability greater than 0.95 (*) or 0.99 (**) are shown. Sites are numbered according to the full human coding sequence.