From: Genealogy of an ancient protein family: the Sirtuins, a family of disordered members
Kinase | Function | Localization | Sirt-1 | Sirt-2 | Sirt-3 | Sirt-4 | Sirt-5 | Sirt-6 | Sirt-7 |
---|---|---|---|---|---|---|---|---|---|
BTK | B lymphocyte development, differentiation and signaling. | Cytoplasm, Cell membrane, Nucleus. | 121-Y | 104-Y | |||||
CDK1 | Control of the eukaryotic cell cycle. | Nucleus, Cytoplasm, Mitochondrion. | 14-S 27-S 47-S 530-T 540-S 682-S | 218-T 280-T 368-S 372-S | 150-T | 36-S | 87-T 178-S | 294-T 303-S 330-S 338-S | 345-T |
CDK2 | Control of the cell cycle | Cytoplasm, Cytoskeleton, Centrosome, Nucleus, Cajal body, Cytoplasm, Endosome. | 14-S 27-S 47-S 530-T 540-S 545-S 682-S | 280-T 365-T 368-S 372-S | 294-T 303-S 330-S 338-S | ||||
CDK4 | Regulate the cell-cycle during G 1 /S transition. | Cytoplasm, Nucleus, Nuclear Membrane. | 14-S 27-S 530-T 540-S 545-S | 98-S 279-S 368-S 372-S | 294-T 303-S 330-S 338-S | 345-T 377-S | |||
CDK5 | Neuronal cell cycle arrest and differentiation | Nucleus, Cell membrane, Cytoplasm. | 27-S 530-T 540-S 545-S | 218-T 368-S | 294-T 303-S 330-S 338-S | ||||
CDK6 | Control of the cell cycle and differentiation | Cytoplasm, Nucleus. | 14-S 545-S | 280-T 372-S | 329-S | ||||
CDK7 | Cell cycle control and in RNA polymerase II-mediated RNA transcription. | Nucleus, Cytoplasm, Perinuclear region. | 27-S 344-T 545-S 549-S 605-S 747-S | 166-T | 94-T 294-T 355-S | 148-T 400-T | |||
DYRK1 | Regulation of DNA damage response and regulation of protein deacetylation | Interchromatin regions of nucleoplasm | 14-S 111-S 538-S 744-S 747-S | 53-S 249-S 372-S | 117-S | 330-S 338-S 355-S | |||
EGFR | Activate signaling cascades; involved in cell-cell adhesion, regulation of apoptotic process, regulation of MAPK | Cell membrane, Endoplasm, Golgi apparatus membrane Nucleus membrane, Endosome membrane. | 642-Y 699-Y | 74-Y | |||||
JAK1 | Involved in the IFN-alpha/beta/gamma signal pathway. | Endomembrane system, Peripheral membrane protein. | 699-Y 742-Y | ||||||
LCK | Developing T-cells and function of mature T-cells in thymus | Cytoplasm, Cell membrane, Lipid rafts. | 121-Y 658-Y 699-Y 742-Y | 104-Y | 165-Y | ||||
MAPK3 | MAPK signal transduction pathway | Cytoplasm, Nucleus. | 27-S 47-S 530-T 540-S | 218-T 280-T 368-S 372-S | 36-S 176-T | 294-T 303-S 330-S 338-S | 345-T | ||
MAPK8 | Cell proliferation, differentiation, migration, transformation and programmed death. | Cytoplasm, Nucleus. | 27-S 530-T 540-S 545-S | 368-S | 36-S | 294-T 330-S 338-S | |||
MAPK9 | Cell proliferation, differentiation, migration, transformation and programmed death. | Cytoplasm, Nucleus. | 27-S 530-T 540-S 682-S | 280-T 368-S 372-S | 330-S 338-S | ||||
MAPK10 | Neuronal proliferation, differentiation, migration and programmed death. | Cytoplasm, Membrane, Lipid-anchor, Nucleus. | 14-S 27-S 540-S 682-S | 368-S 372-S | 303-S 330-S 338-S | ||||
MAPK11 | MAPK pathway and role in cellular responses to proinflammatory cytokines or physical stress | Cytoplasm, Nucleus. | 540-S 545-S 682-S | 98-S 280-T | |||||
MAPK12 | Role in cellular responses to proinflammatory cytokines or physical stress | Cytoplasm, Nucleus, Mitochondrion. | 14-S 27-S 540-S 545-S | 280-T 368-S | 150-T | ||||
PAK1 | T cell receptor signaling pathway, apoptotic process, regulation of cell proliferation | Cell-extracellular matrix contact, Cytoplasm. | 615-S | ||||||
PAK2 | Cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. | Nuclues, Cytoplasm, Cell membrane. | 615-S | ||||||
PKD1 (PRKD1) | DAG signaling, regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) | Cytoplasm, Cell membrane, Golgi apparatus. | 152-T 167-T | ||||||
PLK1 | Cell cycle, centrosome maturation and spindle assembly, removal of cohesins from chromosome arms, anaphase-promoting complex, regulation of mitotic exit and cytokinesis. | Nucleus, Kinetochore, Centrosome, Cytoskeleton. | 538-S 540-S 550-S | 23-S 25-S 365-T 368-S 383-T | 294-T 330-S | 400-T | |||
PRKCA | Organizes subcellular localization of membrane proteins containing PDZ sequence, clustering of receptors, synaptic plasticity. | Perinuclear region, Synapse. | 383-T | 337-S | 229-T | ||||
ZAP70 | Regulation of adaptive immune response, motility, adhesion and cytokine expression of mature T-cells, thymocyte development. development and activation of primary B-lymphocytes. | Cytoplasm, Cell membrane. | 121-Y 699-Y |