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Table 6 Human kinases which are predicted to phosphorylate specific residues in human sirtuins

From: Genealogy of an ancient protein family: the Sirtuins, a family of disordered members

Kinase

Function

Localization

Sirt-1

Sirt-2

Sirt-3

Sirt-4

Sirt-5

Sirt-6

Sirt-7

BTK

B lymphocyte development, differentiation and signaling.

Cytoplasm, Cell membrane, Nucleus.

121-Y

104-Y

     

CDK1

Control of the eukaryotic cell cycle.

Nucleus, Cytoplasm, Mitochondrion.

14-S 27-S 47-S 530-T 540-S 682-S

218-T 280-T 368-S 372-S

150-T

36-S

87-T 178-S

294-T 303-S 330-S 338-S

345-T

CDK2

Control of the cell cycle

Cytoplasm, Cytoskeleton, Centrosome, Nucleus, Cajal body, Cytoplasm, Endosome.

14-S 27-S 47-S 530-T 540-S 545-S 682-S

280-T 365-T 368-S 372-S

   

294-T 303-S 330-S 338-S

 

CDK4

Regulate the cell-cycle during G 1 /S transition.

Cytoplasm, Nucleus, Nuclear Membrane.

14-S 27-S 530-T 540-S 545-S

98-S 279-S 368-S 372-S

   

294-T 303-S 330-S 338-S

345-T 377-S

CDK5

Neuronal cell cycle arrest and differentiation

Nucleus, Cell membrane, Cytoplasm.

27-S 530-T 540-S 545-S

218-T 368-S

   

294-T 303-S 330-S 338-S

 

CDK6

Control of the cell cycle and differentiation

Cytoplasm, Nucleus.

14-S 545-S

280-T 372-S

329-S

    

CDK7

Cell cycle control and in RNA polymerase II-mediated RNA transcription.

Nucleus, Cytoplasm, Perinuclear region.

27-S 344-T 545-S 549-S 605-S 747-S

166-T

   

94-T 294-T 355-S

148-T 400-T

DYRK1

Regulation of DNA damage response and regulation of protein deacetylation

Interchromatin regions of nucleoplasm

14-S 111-S 538-S 744-S 747-S

53-S 249-S 372-S

117-S

  

330-S 338-S 355-S

 

EGFR

Activate signaling cascades; involved in cell-cell adhesion, regulation of apoptotic process, regulation of MAPK

Cell membrane, Endoplasm, Golgi apparatus membrane Nucleus membrane, Endosome membrane.

642-Y 699-Y

  

74-Y

   

JAK1

Involved in the IFN-alpha/beta/gamma signal pathway.

Endomembrane system, Peripheral membrane protein.

699-Y 742-Y

      

LCK

Developing T-cells and function of mature T-cells in thymus

Cytoplasm, Cell membrane, Lipid rafts.

121-Y 658-Y 699-Y 742-Y

104-Y

165-Y

    

MAPK3

MAPK signal transduction pathway

Cytoplasm, Nucleus.

27-S 47-S 530-T 540-S

218-T 280-T 368-S 372-S

 

36-S 176-T

 

294-T 303-S 330-S 338-S

345-T

MAPK8

Cell proliferation, differentiation, migration, transformation and programmed death.

Cytoplasm, Nucleus.

27-S 530-T 540-S 545-S

368-S

 

36-S

 

294-T 330-S 338-S

 

MAPK9

Cell proliferation, differentiation, migration, transformation and programmed death.

Cytoplasm, Nucleus.

27-S 530-T 540-S 682-S

280-T 368-S 372-S

   

330-S 338-S

 

MAPK10

Neuronal proliferation, differentiation, migration and programmed death.

Cytoplasm, Membrane, Lipid-anchor, Nucleus.

14-S 27-S 540-S 682-S

368-S 372-S

   

303-S 330-S 338-S

 

MAPK11

MAPK pathway and role in cellular responses to proinflammatory cytokines or physical stress

Cytoplasm, Nucleus.

540-S 545-S 682-S

98-S 280-T

     

MAPK12

Role in cellular responses to proinflammatory cytokines or physical stress

Cytoplasm, Nucleus, Mitochondrion.

14-S 27-S 540-S 545-S

280-T 368-S

150-T

    

PAK1

T cell receptor signaling pathway, apoptotic process, regulation of cell proliferation

Cell-extracellular matrix contact, Cytoplasm.

615-S

      

PAK2

Cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation.

Nuclues, Cytoplasm, Cell membrane.

615-S

      

PKD1

(PRKD1)

DAG signaling, regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2)

Cytoplasm, Cell membrane, Golgi apparatus.

     

152-T 167-T

 

PLK1

Cell cycle, centrosome maturation and spindle assembly, removal of cohesins from chromosome arms, anaphase-promoting complex, regulation of mitotic exit and cytokinesis.

Nucleus, Kinetochore, Centrosome, Cytoskeleton.

538-S 540-S 550-S

23-S 25-S 365-T 368-S 383-T

   

294-T 330-S

400-T

PRKCA

Organizes subcellular localization of membrane proteins containing PDZ sequence, clustering of receptors, synaptic plasticity.

Perinuclear region, Synapse.

 

383-T

337-S

  

229-T

 

ZAP70

Regulation of adaptive immune response, motility, adhesion and cytokine expression of mature T-cells, thymocyte development. development and activation of primary B-lymphocytes.

Cytoplasm, Cell membrane.

121-Y 699-Y

      
  1. In red the kinases acting on N-terminal residues, in green on cores and in light blue on C-terminal. Phosphosites predicted but already experimentally determined are indicated underlined and in bold. In the table known functions and cellular locations exerted by these kinases are also reported [Shchemelinin et al., 2006.