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Table 1 Non-synonymous mutations in the rpoB gene conferring rifampicin resistance

From: Evolution of Escherichia coli rifampicin resistance in an antibiotic-free environment during thermal stress

High temperature adapted clones

Nucleotide change

Amino acid change

Mutation change

Codon change

Phenotype (MIC in Rifampicin)

Level of rifampicin resistance

56

ATC → TTC

Ile (I) → Phe (F)

A1714T

I572F

800 μg/mL

VERY HIGH

61

ATC → TTC

Ile (I) → Phe (F)

A1714T

I572F

800 μg/mL

 

27

ATC → CTC

Ile (I) → Leu (L)

A1714C

I572L

100 μg/mL

HIGH

35

ATC → CTC

Ile (I) → Leu (L)

A1714C

I572L

100 μg/mL

92

ATC → CTC

Ile (I) → Leu (L)

A1714C

I572L

100 μg/mL

97

ATC → CTC

Ile (I) → Leu (L)

A1714C

I572L

100 μg/mL

142

ATC → CTC

Ile (I) → Leu (L)

A1714C

I572L

100 μg/mL

 

4

ATC → AAC

Ile (I) → Asn (N)

T1715A

I572N

50 μg/mL

INTERMEDIATE

43

ATC → AAC

Ile (I) → Asn (N)

T1715A

I572N

25 μg/mL

77

ATC → AAC

Ile (I) → Asn (N)

T1715A

I572N

25 μg/mL

112

ATC → AAC

Ile (I) → Asn (N)

T1715A

I572N

50 μg/mL

131

ATC → AAC

Ile (I) → Asn (N)

T1715A

I572N

25 μg/mL

59

CGT → CTT

Arg (R) → Leu (L)

G428T

R143L

25 μg/mL

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