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Table 3 Evolutionary properties of human proteins of different age

From: Emergence of novel domains in proteins

  Age N proteins Domains/prot. Protein length* dN/dSa*
Proteins with domains      
  Old 11,039 1.91 (1) 616.3 (473) 0.11 (0.08)
  Vertebrate 473 1.15 (1) 394.3 (269) 0.21 (0.18)
  Mammalian 62 1.02 (1) 267.9 (163) 0.35 (0.33)
Proteins without domains      
  Old 1,816 NA 654.6 (501) 0.15 (0.12)
  Vertebrate 851 NA 449.0 (319) 0.21 (0.18)
  Mammalian 358 NA 308.2 (214.5) 0.39 (0.31)
  1. Mean and median (in brackets) are shown. aNon-synonymous to synonymous substitution rate (dN/dS) was calculated for 10,636 Old, 416 Vertebrate and 40 Mammalian proteins with domains, and for 1,740 Old, 784 Vertebrate and 274 Mammalian proteins without domains. *Kolmogorov-Smirnov test p < 10-5 in all pairwise comparisons.