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Table 3 Measures of ongoing selective pressures in human populations for a subset of telomere associated genes

From: Molecular adaptation of telomere associated genes in mammals

Gene name and significance level

iHS

A

C

Y

Total SNPs

ATM @5%

> +2

3

5

0

158

< -2

0

3

18

BRCA1 @5%

> +2

0

1

0

108

< -2

0

0

1

WRN @10%

> +2

0

2

2

306

< -2

0

1

10

RBL1 @10%

> +2

0

0

0

88

< -2

1

0

0

ANKHD1 @5%

> +2

0

0

0

49

< -2

0

1

1

  1. Each gene identified as diverging within the ancestral human population at p-adj (0.05) and p-adj (0.10) significance levels under the CladeC model are listed with the number of SNPs with iHS > 2 and the number of SNPs with an iHS < -2 for the East Asian (A), northern and Western European (C), and African Yoruba (Y) populations. The total number of SNPs known for each gene is given in the final column.