Positive selection in the adhesion domain of Mus sperm Adam genes through gene duplications and function-driven gene complex formations

Table 1 Branch and site tests of selection in Mus

Gene	l	n	2Δℓ M0N0	ω	Branch	2Δℓ	p ₁ ; ω (M8)	Site
Gene	l	n	(ω vs ω = 1.0)	ω	Selection	(M8-M8a)	p ₁ ; ω (M8)	Selection
Adam1a	321	5	9.78	0.16	Purifying	0		Purifying
Adam1b	321	5	0.03	0.91	Relaxed	3.89	0.07; 9.10	Positive
Adam1	321	10	63.11	0.21	Purifying	1.94		Purifying
Adam2	333	5	0.2	0.78	Relaxed	9.77	0.11; 12.87	Positive
Adam3	339	5	0.04	0.89	Relaxed	4.08	0.13; 8.92	Positive
Adam4a	327	5	6.18	0.22	Purifying	0		Purifying
Adam4b	327	5	3.25	4.69	Purifying	15.36	0.04; 38.74	Positive
Adam4	327	10	0.8	1.39	Relaxed	49.84	0.07; 23.54	Positive
Adam5	273	5	4.36	3.78	Positive	24.38	0.20; 30.03	Positive
Adam6a	327	5	9.75	0.21	Purifying	2.02		Purifying
Adam6b	327	5	9.74	0.17	Purifying	0.65		Purifying
Adam6	327	10	11.67	0.32	Purifying	8.15	0.08; 5.69	Positive
Adam7	267	5	11.03	0.15	Purifying	0		Purifying
Adam18	339	5	1.96	0.46	Relaxed	2.21		Purifying
Adam24	330	5	0.06	1.15	Relaxed	7.64	0.06; 19.11	Positive
Adam26a	327	4	0.07	0.87	Relaxed	1.53		Purifying
Adam26b	327	4	1.35	0.5	Relaxed	0.11		Purifying
Adam26	327	7	0.24	0.78	Relaxed	4.03	0.29; 3.63	Positive
Adam30	327	5	7.95	0.14	Purifying	0		Purifying
Adam32	285	5	1.91	0.46	Relaxed	0.01		Purifying

n = number of species included; l = length of adhesion domain analyzed (bp); 2Δℓ = the difference in likelihood estimates from different models of selection; ω= d_N/d_S per codon for sites under positive selection; p₁ = proportion of codon sites under positive selection. Test statistics (2Δℓ) are bolded (FDR corrected P < 0.05) or underlined (FDR corrected P < 0.10) to denote statistical significance.

ISSN: 2730-7182