Figure 3

Genomic neighborhood of leuS in the Halobacteriales and other Archaea. The central red arrow represents the gene encoding LeuRS. The type of LeuRS is indicated on the right hand side of each gene neighborhood. Genes depicted in the same color (except light yellow and white) are from the same cluster of orthologous genes (COG), light yellow and white arrows indicate genes without COG assignment and pseudogenes, respectively. While the gene neighborhood of the archaeal type LeuRS is conserved in the depicted haloarchaea and in methanogenic archaea (but not between the two groups), the gene neighborhood of type B LeuRS appears less conserved, revealing frequent non-homologous recombination and rearrangements. See text for further discussion. Genes flanking leuS marked with # and * refer to alanine dehydrogenase and a thermosome subunit, respectively.