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Figure 4 | BMC Evolutionary Biology

Figure 4

From: The mammary gland-specific marsupial ELP and eutherian CTI share a common ancestral gene

Figure 4

Chromosomal location of the ELP/CTI gene in different species. The ELP/CTI gene was located within a syntenic block on opossum Chr. 1 (~501.34 Mb), human Chr. 20q12-13.12, mouse Chr. 2 H3, dog chr. 24 (~35.7 Mb) and cow Chr. 13 (~74.5 Mb) [49, 55]. However, ELP/CTI was reduced to a pseudogene in the human and mouse (red arrow, white diagonal stripes) and was absent in the chicken and zebrafish. The ELP/CTI gene was located on the reverse strand and was generally flanked by one, or both of the single-copy genes PIGT and WFDC2. The region upstream of PIGT was conserved in mammals and the chicken and included the SYS1 [Golgi-localized integral membrane protein homolog (S. cerevisiae)], TP53TG5 (TP53-target gene 5 protein), and DBNDD2 dysbindin (dystrobrevin binding protein 1) domain containing 2 genes. However, a chromosomal breakpoint was located downstream from the eutherian WFDC2 gene. Opossum chromosome 1 contained the AEBP1 (Adipocyte enhancer binding protein 1), POLD2 polymerase (DNA directed), delta 2, regulatory subunit 50 kDa, MYL7 (myosin, light chain 7, regulatory) and YKT6 YKT6 v-SNARE homolog (S. cerevisiae)] genes and was orthologous to human chromosome 7p13-p15.1. In contrast, the eutherian chromosomes contained a number of genes which encoded Kunitz and/or WAP domains. These included SPINT3 SPINLW1 WFDC8 and WFDC6, which were likely to have arisen by gene and domain duplications [62]. Notably, there was an insert of ~602 kb between bovine CTI and WFDC2. Arrows indicate the arrangement and orientation of genes and are not drawn to scale.

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