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Figure 2 | BMC Evolutionary Biology

Figure 2

From: Phylogenomics of phosphoinositide lipid kinases: perspectives on the evolution of second messenger signaling and drug discovery

Figure 2

Phylogenetic tree of phosphoinositide 3-kinases (PI3K) and Type III phosphoinositide 4-kinases (PI4K). PI3K proteins are labeled according to HUGO human gene name with classes identified by commonly accepted nomenclature [2]. Main organism taxonomic groups are color coded. For simplicity, Protosomatia (insects/arthropods), Pseudocoelomata (nematode worms) are considered collectively as Invertebrates. The tree was reconstructed by neighbor-joining (NJ) method using protein distance matrices of core conserved amino acids (see Methods). Asterisks ("*") indicate those nodes supported 70% or greater in 1000 bootstrap replicate NJ trees and 0.95 Bayesian posterior probability. Scale bar represents 0.1 expected amino acid residue substitutions per site.

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