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Table 4 Comparison of the accessible surface area (ASA) values of atypical amino acid replacement sites with those of all sites in gapless alignments

From: Molecular evolution of cyclin proteins in animals and fungi

 

Skewness of atypical replacement samples to positions in the protein globule

 

Interior positions in globule (p)*

Surface positions in globule (p)*

Cyclin families

DSSP ASA values

10 ASA

classes

3 ASA

classes

DSSP ASA values

10 ASA

classes

3 ASA

classes

A animal

0.9966

0.9957

0.9906

0.0034

0.0043

0.0095

B animal

0.9570

0.9772

0.9678

0.0432

0.0230

0.0324

B fungal

0.6029

0.7785

0.7500

0.3983

0.2224

0.2512

B3 animal

0.9914

0.9975

0.9827

0.0087

0.0025

0.0175

D animal

0.9713

0.9200

0.8835

0.0289

0.0805

0.1173

E animal

0.9995

0.9999

0.9999

0.0005

0.0001

0.0001

  1. *Distribution skewness was estimated using one-tailed Mann-Whitney's test.
  2. p ≤ 0.005 is in bold, 0.005 <p ≤ 0.025 is in italics; Bonferonni's correction for simultaneous testing of two statistical hypotheses based on the same dataset: accessible surface area and atypical amino acid replacements positions.