Figure 1

Classification of upstream open reading frames (uORFs) and potential effects of non-3n indels when they occur between uAUGs and TISs. (A) The open circle represents the 5'-cap structure of the transcript. The solid- and dashed-line open boxes represent the main coding sequences and the uORFs, respectively. The open and solid inverted triangles, respectively, indicate the locations of the uAUGs and the translation initiation sites (TIS). The open and solid triangles indicate locations of the stop codons of the uORFs and the main coding sequences. (B) Symbols "○", "×", and "?" represent that the protein isoforms or protein expression "is affected", "is not affected", and "uncertain", respectively.